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Animal Models of Neurodevelopmental Disorders pp 239–246Cite as

Animal Models of Cerebral Dysgenesis: Excitotoxic Brain Injury

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Part of the book series: Neuromethods ((NM,volume 104))

Abstract

Brain damage through excitotoxic mechanisms is a major cause of pediatric neurologic diseases. These include hypoxic-ischemic encephalopathy, periventricular white matter damage (PWMD), stroke, meningoencephalitis, traumatic brain injury, and neurodegenerative disorders. In the present chapter, we describe the procedure to generate a model of excitotoxic injury by intra-cerebrally injecting glutamate analogues. This model provides tools for investigating excitotoxic influences at various stages of neural development and for identifying protective substances against excitotoxicity.

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Author information

Authors and Affiliations

  1. Inserm, U1141, Paris, France

    Luigi Titomanlio, Leslie Schwendimann & Pierre Gressens M.D., Ph.D.

  2. Univ Paris Diderot, Sorbonne Paris Cité, UMRS 1141, Paris, France

    Luigi Titomanlio, Leslie Schwendimann & Pierre Gressens M.D., Ph.D.

  3. PremUP, Paris, France

    Luigi Titomanlio, Leslie Schwendimann & Pierre Gressens M.D., Ph.D.

  4. AP-HP, Pediatric Emergency Department, Hôpital Robert Debré, Paris, France

    Luigi Titomanlio

  5. Centre for the Developing Brain, Department of Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital, London, UK

    Pierre Gressens M.D., Ph.D.

Authors
  1. Luigi Titomanlio
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  2. Leslie Schwendimann
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  3. Pierre Gressens M.D., Ph.D.
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Corresponding author

Correspondence to Pierre Gressens M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Div. Pediatric Neurology, University of Alberta Dept. Pediatrics, Edmonton, Alberta, Canada

    Jerome Y. Yager

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Titomanlio, L., Schwendimann, L., Gressens, P. (2015). Animal Models of Cerebral Dysgenesis: Excitotoxic Brain Injury. In: Yager, J. (eds) Animal Models of Neurodevelopmental Disorders. Neuromethods, vol 104. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2709-8_15

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  • DOI: https://doi.org/10.1007/978-1-4939-2709-8_15

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-2708-1

  • Online ISBN: 978-1-4939-2709-8

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