Abstract
Brain damage through excitotoxic mechanisms is a major cause of pediatric neurologic diseases. These include hypoxic-ischemic encephalopathy, periventricular white matter damage (PWMD), stroke, meningoencephalitis, traumatic brain injury, and neurodegenerative disorders. In the present chapter, we describe the procedure to generate a model of excitotoxic injury by intra-cerebrally injecting glutamate analogues. This model provides tools for investigating excitotoxic influences at various stages of neural development and for identifying protective substances against excitotoxicity.
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Titomanlio, L., Schwendimann, L., Gressens, P. (2015). Animal Models of Cerebral Dysgenesis: Excitotoxic Brain Injury. In: Yager, J. (eds) Animal Models of Neurodevelopmental Disorders. Neuromethods, vol 104. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2709-8_15
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DOI: https://doi.org/10.1007/978-1-4939-2709-8_15
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-2708-1
Online ISBN: 978-1-4939-2709-8
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