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Nanotechnology for Nucleic Acid Delivery pp 1–12Cite as

Toxicological Aspects for Nanomaterial in Humans

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 948))

Abstract

Among beneficial applications of nanotechnology, nanomedicine offers perhaps the greatest potential for improving human conditions and quality of life. Engineered nanomaterials (ENMs), with their unique properties, have potential to improve therapy of many human disorders. The properties that make ENMs so useful could also lead to unintentional adverse health effects. Challenges arising from physicochemical properties of ENMs, their characterization, exposure, and hazard assessment and other key issues of ENM safety are discussed. There is still scant knowledge about ENM cellular uptake, transport across biological barriers, distribution within the body, and possible mechanisms of toxicity. The safety of ENMs should be tested to minimize possible risk before the application. However, existing toxicity tests need to be adapted to fit to the unique features related to the nanosized material and appropriate controls and reference material should be considered.

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Acknowledgment

Supported by European Commission Seventh Framework Programme [Health-2007-1.3-4], Contract no: 201335, www.nanotest-fp7.eu

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Authors and Affiliations

  1. NILU, CEE, Health Effects Group, Kjeller, Norway

    Maria Dusinska, Zuzana Magdolenova & Lise Marie Fjellsbø

Authors
  1. Maria Dusinska
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  2. Zuzana Magdolenova
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  3. Lise Marie Fjellsbø
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Corresponding author

Correspondence to Maria Dusinska .

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Editors and Affiliations

  1. , Department of Pharmacy, Ludwig-Maximilians-University Munich, Butenandstraße 5-13, Munich, 81377, Germany

    Manfred Ogris

  2. , Department of Pharmaceutical Sciences, Wayne State University, Mack Avenue 259, Detroit, 48201, USA

    David Oupicky

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Dusinska, M., Magdolenova, Z., Fjellsbø, L.M. (2013). Toxicological Aspects for Nanomaterial in Humans. In: Ogris, M., Oupicky, D. (eds) Nanotechnology for Nucleic Acid Delivery. Methods in Molecular Biology, vol 948. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-140-0_1

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  • DOI: https://doi.org/10.1007/978-1-62703-140-0_1

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  • Publisher Name: Humana Press, Totowa, NJ

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