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Photodynamic Therapy pp 155–173Cite as

Antimicrobial Photodynamic Inactivation and Photodynamic Therapy for Infections

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 635))

Abstract

Photodynamic therapy (PDT) was initially discovered over 100 years ago by its ability to kill microorganisms, but its use to treat infections clinically has not been much developed. However, the present relentless increase in antibiotic resistance worldwide and the emergence of strains that are resistant to all known antibiotics has stimulated research into novel antimicrobial strategies such as PDT that are thought to be unlikely to lead to the development of resistance. In this chapter we will cover the use of PDT to kill pathogenic microbial cells in vitro and describe a mouse model of localized infection and its treatment by PDT without causing excessive damage to the host tissue.

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Author information

Authors and Affiliations

  1. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA

    Liyi Huang, Tianhong Dai & Michael R. Hamblin

  2. Department of Dermatology, Harvard Medical School, Boston, MA, USA

    Liyi Huang, Tianhong Dai & Michael R. Hamblin

  3. Department of Infectious Diseases, First Affiliated College and Hospital, Guangxi Medical University, Nanning, China

    Liyi Huang

  4. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA

    Michael R. Hamblin

Authors
  1. Liyi Huang
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  2. Tianhong Dai
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  3. Michael R. Hamblin
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Editor information

Editors and Affiliations

  1. Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Sunset Blvd. 4650, Los Angeles, 90027, California, USA

    Charles J. Gomer

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Huang, L., Dai, T., Hamblin, M.R. (2010). Antimicrobial Photodynamic Inactivation and Photodynamic Therapy for Infections. In: Gomer, C. (eds) Photodynamic Therapy. Methods in Molecular Biology, vol 635. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-697-9_12

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  • DOI: https://doi.org/10.1007/978-1-60761-697-9_12

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-696-2

  • Online ISBN: 978-1-60761-697-9

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