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Antimicrobial Peptides pp 303–327Cite as

Potential Therapeutic Application of Host Defense Peptides

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 618))

Abstract

Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines. In addition, HDPs also provide a range of immunomodulatory activities related to innate immunity defense, inflammation, and wound healing. The development of these multi-faceted molecules and their bioactivities into clinically important therapeutics is being pursued using a number of different approaches. Here we review the role of HDPs in nature and application of this role to the development of novel therapeutics.

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Authors and Affiliations

  1. Helix Biomedix Inc., Bothell, WA, USA

    Lijuan Zhang & Timothy J. Falla

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  1. Lijuan Zhang
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  2. Timothy J. Falla
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  1. SpiderBiotech S.r.l., Via Ribes 5, Colleretto Giacosa, 10010, Torino, Italy

    Andrea Giuliani

  2. Dipto. Scienze e Tecnologie Biomediche, Università di Cagliari, Monserrato, 09042, Italy

    Andrea C. Rinaldi

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Zhang, L., Falla, T.J. (2010). Potential Therapeutic Application of Host Defense Peptides. In: Giuliani, A., Rinaldi, A. (eds) Antimicrobial Peptides. Methods in Molecular Biology, vol 618. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-594-1_19

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  • DOI: https://doi.org/10.1007/978-1-60761-594-1_19

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-593-4

  • Online ISBN: 978-1-60761-594-1

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