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Quantitative Trait Loci Mapping

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Book cover Osteoporosis

Part of the book series: Methods In Molecular Biology™ ((MIMB,volume 455))

Abstract

This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems.

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Acknowledgments

Investigators of this work were partially supported by grants from NIH (R01 AR050496, K01 AR02170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the state of Nebraska. The study also benefited from grants from National Science Foundation of China, Huo Ying Dong Education Foundation, HuNan Province, Xi'an Jiaotong University, and the Ministry of Education of China.

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Authors and Affiliations

  1. Osteoporosis Research Center, Creighton University, Omaha, NE

    Dong-Hai Xiong & Robert R Recker

  2. Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri-Kansas City, Kansas City, MO

    Jian-Feng Liu & Hong-Wen Deng

  3. The Key Laboratory of Biomedical Information Engineering of Ministry of Education and Institute of Molecular Genetic, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, P.R. China

    Yan-Fang Guo, Yan Guo & Tie-Lin Yang

  4. Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P.R. China

    Hui Jiang, Yuan Chen & Fang Yang

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  1. Dong-Hai Xiong
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  2. Jian-Feng Liu
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  3. Yan-Fang Guo
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  4. Yan Guo
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  5. Tie-Lin Yang
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  6. Hui Jiang
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  7. Yuan Chen
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  8. Fang Yang
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  9. Robert R Recker
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  10. Hong-Wen Deng
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Editors and Affiliations

  1. Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA

    Jennifer J. Westendorf

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Xiong, DH. et al. (2008). Quantitative Trait Loci Mapping. In: Westendorf, J.J. (eds) Osteoporosis. Methods In Molecular Biology™, vol 455. Humana Press. https://doi.org/10.1007/978-1-59745-104-8_16

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  • DOI: https://doi.org/10.1007/978-1-59745-104-8_16

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-828-7

  • Online ISBN: 978-1-59745-104-8

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