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RNA Systems Biology for Cancer: From Diagnosis to Therapy

  • Protocol
Systems Medicine

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1386))

Abstract

It is due to the advances in high-throughput omics data generation that RNA species have re-entered the focus of biomedical research. International collaborate efforts, like the ENCODE and GENCODE projects, have spawned thousands of previously unknown functional non-coding RNAs (ncRNAs) with various but primarily regulatory roles. Many of these are linked to the emergence and progression of human diseases. In particular, interdisciplinary studies integrating bioinformatics, systems biology, and biotechnological approaches have successfully characterized the role of ncRNAs in different human cancers. These efforts led to the identification of a new tool-kit for cancer diagnosis, monitoring, and treatment, which is now starting to enter and impact on clinical practice. This chapter is to elaborate on the state of the art in RNA systems biology, including a review and perspective on clinical applications toward an integrative RNA systems medicine approach. The focus is on the role of ncRNAs in cancer.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran

    Raheleh Amirkhah & Ali Farazmand

  2. Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer & Ulf Schmitz

  3. Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Stellenbosch, South Africa

    Olaf Wolkenhauer

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  1. Raheleh Amirkhah
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  2. Ali Farazmand
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  3. Olaf Wolkenhauer
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  4. Ulf Schmitz
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Correspondence to Ulf Schmitz .

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Editors and Affiliations

  1. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Ulf Schmitz

  2. Dept of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

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Amirkhah, R., Farazmand, A., Wolkenhauer, O., Schmitz, U. (2016). RNA Systems Biology for Cancer: From Diagnosis to Therapy. In: Schmitz, U., Wolkenhauer, O. (eds) Systems Medicine. Methods in Molecular Biology, vol 1386. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3283-2_14

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  • DOI: https://doi.org/10.1007/978-1-4939-3283-2_14

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