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Cardiac Tissue Engineering pp 167–176Cite as

Collagen-Based Engineered Heart Muscle

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 1181))

Abstract

Cardiac muscle engineering has evolved over nearly 20 years from a scientific oddity to a mainstream technology with a wide range of applications. Of the many published methods it appears that hydrogels constitute the preferred scaffolds for myocardial tissue engineering and support of organotypic development. Here we describe a simple and highly robust protocol for the generation of engineered heart muscle using a collagen-based hydrogel method.

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Acknowledgements

M.T. is supported by the University Medical Center Göttingen (Startförderung I). W.H.Z. is supported by the DZHK (German Center for Cardiovascular Research), German Federal Ministry for Science and Education (BMBF FKZ 01GN0827, FKZ 01GN0957), the German Research Foundation (DFG ZI 708/7-1, 8-1, 10-1, SFB 1002), European Union FP7 CARE-MI, CIRM/BMBF FKZ 13GW0007A, and NIH U01 HL099997.

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Authors and Affiliations

  1. Institute of Pharmacology, Heart Research Center Göttingen (HRCG), University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    Malte Tiburcy, Tim Meyer, Poh Loong Soong & Wolfram-Hubertus Zimmermann M.D.

  2. DZHK (German Center for Cardiovascular Research), partner site Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    Malte Tiburcy, Tim Meyer, Poh Loong Soong & Wolfram-Hubertus Zimmermann M.D.

Authors
  1. Malte Tiburcy
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  2. Tim Meyer
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  3. Poh Loong Soong
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  4. Wolfram-Hubertus Zimmermann M.D.
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Corresponding author

Correspondence to Wolfram-Hubertus Zimmermann M.D. .

Editor information

Editors and Affiliations

  1. Department Chemical Engineering&Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

    Milica Radisic

  2. Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA

    Lauren D. Black III

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Tiburcy, M., Meyer, T., Soong, P.L., Zimmermann, WH. (2014). Collagen-Based Engineered Heart Muscle. In: Radisic, M., Black III, L. (eds) Cardiac Tissue Engineering. Methods in Molecular Biology, vol 1181. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1047-2_15

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  • DOI: https://doi.org/10.1007/978-1-4939-1047-2_15

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-1046-5

  • Online ISBN: 978-1-4939-1047-2

  • eBook Packages: Springer Protocols

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