Gastrointestinal Stromal Tumor

1. Front Matter

   Pages i-ix

   PDF

2. Epidemiology

   • Takahiro Higashi

   Pages 1-9

3. Histology

   • Hidetaka Yamamoto

   Pages 11-30

4. Genetics

   • Tsuyoshi Takahashi

   Pages 31-48

5. Diagnostic Imaging of Gastrointestinal Stromal Tumor

   • Tomohiro Yoneyama, Bae Hyeyeol, Yoshio Kitazume, Mitsuhiro Kishino, Ukihide Tateishi

   Pages 49-59

6. Risk Classification

   • Hirotoshi Kikuchi, Hiroyuki Konno, Hiroya Takeuchi

   Pages 61-77

7. Treatment Guidelines

   • Muranaka Tetsuhito, Yoshito Komatsu

   Pages 79-87

8. Surgery

   • Souya Nunobe

   Pages 89-107

9. First-Line Treatment

   • Yusuke Onozawa

   Pages 109-115

10. Second- and Third-Line Treatment

    • Masato Ozaka

    Pages 117-127

11. Adjuvant and Neoadjuvant Treatment

    • Haruhiko Cho

    Pages 129-144

12. New Agents for Gastrointestinal Stromal Tumors

    • Yoichi Naito, Toshihiko Doi

    Pages 145-156

This book provides a comprehensive and up-to-date overview of gastrointestinal stromal tumors (GISTs).

GISTs represent the most common mesenchymal neoplasms arising within the gastrointestinal tract. The causative gene of this disease was originally discovered in Japan by Prof. Seichi Hirota in 1998, and since then numerous important advances – from basic to clinical aspects – have been reported from Japan. Professionals involved in the management of GISTs inevitably cite significant evidence and the state-of-the-art treatments from the Asian region, where has there is and inherently high prevalence of gastrointestinal cancers.

Each expert author elucidates the cutting-edge knowledge on pathophysiology, diagnosis, and treatment of GISTs, especially focusing on the highly valuable data from Japan. This attractive collection benefits not only oncologists but also basic researchers, general physicians and surgeons, as well as paramedical staff and medical students who are dealing with GISTs.

• Gastrointestinal cancer
• Gastrointestinal tract
• Mesenchymal neoplasm
• Imatinib
• Malignancy
• surgical oncology

“The audience includes students, researchers, residents, oncologists, and surgeons. ... It includes the current knowledge regarding demographics and characteristics of at‐risk groups, the newest evaluation of individual tumors with helpful color photographs of tumor slides, and detailed descriptions of different aspects of tumor genetics, with illustrations of signal mapping and mutations. … This is as comprehensive a book on GIST as I can imagine, and it fills knowledge gaps for clinicians caring for these patients.” (Ryan Lehmann, Doody's Book Reviews, June 21, 2019)​

• Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan

  Yukinori Kurokawa

• Department of Cancer Chemotherapy, Hokkaido University Hospital Cancer Center, Sapporo, Japan

  Yoshito Komatsu

Dr. Yukinori Kurokawa,

Assistant Professor,

Department of Gastoenterological Surgery,

Graduate School of Medicine,

Osaka University

Dr. Yoshito Komatsu,

Associate Professor,

Department of Cancer Chemotherapy,

Hokkaido University Hospital Cancer Center

Policies and ethics