Hematopoietic Differentiation of Human Pluripotent Stem Cells

1. Front Matter

   Pages i-vi

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2. Generation of Hemangioblasts from Human Pluripotent Stem Cells

   • Shi-Jiang Lu, Qiang Feng, Robert Lanza

   Pages 1-13

3. Derivation of Mature Erythrocytes from Human Pluripotent Stem Cells by Coculture with Murine Fetal Stromal Cells

   • Bin Mao, Xulin Lu, Shu Huang, Jinfeng Yu, Mowen Lai, Kohichiro Tsuji et al.

   Pages 15-39

4. Derivation of Megakaryocytes and Platelets from Human Pluripotent Stem Cells

   • Yanfeng Li, Ying Wang, Linzhao Cheng, Zack Z. Wang

   Pages 41-50

5. Derivation of Functionally Mature Eosinophils from Human Pluripotent Stem Cells

   • Ya Zhou, Xu Pan, Wenyu Yang, Yanzheng Gu, Bin Mao, Mowen Lai et al.

   Pages 51-68

6. Human Pluripotent Stem Cells as a Renewable Source of Natural Killer Cells

   • David L. Hermanson, Zhenya Ni, Dan S. Kaufman

   Pages 69-79

7. Generation of T-Lineage Cells from iPS Cells and Its Application

   • Haruka Wada, Muhammad Baghdadi, Ken-ichiro Seino

   Pages 81-90

8. Reprogramming of Human Cord Blood CD34+ Cells into Induced MSCs

   • Amanda Neises, Ruijun Jeanna Su, Xiao-Bing Zhang

   Pages 91-101

9. CRISPR/Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells

   • Jian-Ping Zhang, Amanda Neises, Tao Cheng, Xiao-Bing Zhang

   Pages 103-116

10. Humanized Mouse Models with Functional Human Lymphoid and Hematopoietic Systems Through Human Hematopoietic Stem Cell and Human Fetal Thymic Tissue Transplantation

    • Zheng Hu, Feng Jin, Bing Chen, Jinglong Guo, Jin He, Zhigang Liu et al.

    Pages 117-128

This book features the most cutting-edge work from the world’s leading laboratories in this field and provides practical methods for differentiating pluripotent stem cells into hematopoietic lineages in the blood system. Pluripotent stem cells have attracted major interest from a fast-growing and multidisciplinary community of researchers who are developing new techniques for the derivation and differentiation of these cells into specific cell lineages. These direct differentiation methods hold great promise for the translational applications of these cells. This book is an essential reference work for researchers at all levels in the fields of hematology and stem cell biology, as well as clinical practitioners in regenerative medicine.

• Crispr/Cas9-Mediated Genome Editing
• Pluripotent stem cells
• T cells
• hematopoietic differentiation
• programming and reprogramming
• regenerative medicine

• Institute of Hematology, Tianjin, China

  Tao Cheng

Tao Cheng is a professor and director of the State Key Laboratory of Experimental Hematology. He is also the vice president of Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China. He serves on the Editorial Boards of a number of well-known international journals, such as Leukemia, Experimental Hematology, and International Journal of Hematology. His research interests focus on hematology and stem cells. He has contributed enormously to our understanding of the cell cycle control of hematopoietic stem cells and has published more than 20 original research articles in top journals over the last 5 years.

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