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Mitochondrial Dynamics and Neurodegeneration

  • Book
  • © 2011

Overview

Editors:
  1. Bingwei Lu

    1. , Department of Pathology, Stanford University School of Medicine, Stanford, USA

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  • Comprehensive reviews written by leading researchers in the field
  • Numerous color figures and illustration to help the readers to better grasp the topics
  • A chapter on mitophagy, one of the most intensely studied topics in neurodegenerative diseases research
  • Includes supplementary material: sn.pub/extras

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xii
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  2. The Genetics of Mitochondrial Fusion and Fission

    • Eliana Y. L. Chan, Jarungjit Rujiviphat, G. Angus McQuibban
    Pages 1-46

  3. Relationships Between Mitochondrial Dynamics and Bioenergetics

    • Giovanni Benard, Nadège Bellance, Caroline Jose, Rodrigue Rossignol
    Pages 47-68

  4. Mitochondrial Dynamics and Autophagy

    • Linsey Stiles, Andrew Ferree, Orian Shirihai
    Pages 69-108

  5. Mitochondrial Dynamics and Apoptosis

    • Megan M. Cleland, Richard J. Youle
    Pages 109-138

  6. Mitochondrial Dynamics and Axonal Transport

    • Qian Cai, Zu-Hang Sheng
    Pages 139-168

  7. Neurological Diseases Associated with Mutations in the Mitochondrial Fusion Machinery

    • Guy Lenaers, Dominique Bonneau, Cécile Delettre, Patrizia Amati-Bonneau, Emmanuelle Sarzi, Dan Miléa et al.
    Pages 169-196

  8. Mitochondrial Fission-Fusion and Parkinson’s Disease: A Dynamic Question of Compensatory Networks

    • Charleen T. Chu, Sarah B. Berman
    Pages 197-213

  9. Role of the Mitochondrial Fission Protein Drp1 in Synaptic Damage and Neurodegeneration

    • Tomohiro Nakamura, Dong-Hyung Cho, Stuart A. Lipton
    Pages 215-234

  10. Mitochondrial Dynamics and Huntington’s Disease: A Dance of Fate

    • Hongmin Wang, Mariusz Karbowski, Mervyn J. Monteiro
    Pages 235-257

  11. Back Matter

    Pages 259-260
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Keywords

About this book

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Reviews

From the reviews:

“The roles of various genes in the process of neurodegeneration is studied and published within this volume. The book ir primarily for biochemists, neuroscientists, and geneticists at all levels of training. I recommend it without any reservations.” (Joseph Grenier, Amazon.com, October, 2013)

Editors and Affiliations

  • , Department of Pathology, Stanford University School of Medicine, Stanford, USA

    Bingwei Lu

Bibliographic Information

  • Book Title: Mitochondrial Dynamics and Neurodegeneration

  • Editors: Bingwei Lu

  • DOI: https://doi.org/10.1007/978-94-007-1291-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2011

  • Hardcover ISBN: 978-94-007-1290-4Published: 18 May 2011

  • Softcover ISBN: 978-94-007-9947-9Published: 18 October 2014

  • eBook ISBN: 978-94-007-1291-1Published: 16 May 2011

  • Edition Number: 1

  • Number of Pages: XII, 260

  • Topics: Neurosciences, Neurobiology

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