Recent Advances in Thrombosis and Hemostasis

1. Front Matter

   Pages I-XXI

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2. Coagulation Mechanism

   1. Front Matter

      Pages 1-1

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   2. Structure and Functions of Fibrinogen and Fibrin

      • Michael W. Mosesson

      Pages 3-26

   3. Vitamin K Cycles and γ-Carboxylation of Coagulation Factors

      • Darrel W. Stafford, Christine M. Hebling

      Pages 27-44

   4. Synthesis and Secretion of Coagulation Factor VIII

      • Michael U. Callaghan, Randal J. Kaufman

      Pages 45-67

   5. Structure and Biological Function of Factor XI

      • Kazuo Fujikawa

      Pages 68-79

   6. Structural Insights into the Life History of Thrombin

      • James A. Huntington

      Pages 80-106

   7. A Molecular Model of the Human Prothrombinase Complex

      • Stephen J. Everse, Ty E. Adams, Kenneth G. Mann

      Pages 107-132

   8. Lipid Mediators and Tissue Factor Expression

      • Hiroyuki Takeya, Koji Suzuki

      Pages 133-146

   9. Tissue Factor Pathway Inhibitor: Structure and Function

      • Hisao Kato

      Pages 147-161

   10. Biology of an Antithrombotic Factor—ADAMTS13

       • Fumiaki Banno, Toshiyuki Miyata

       Pages 162-176

   11. Antithrombin and Heparin Cofactor II: Structure and Functions

       • Takehiko Koide

       Pages 177-189

3. Endothelial Cells and Inflammation

   1. Front Matter

      Pages 191-191

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   2. High-Mobility Group Box 1: Missing Link Between Thrombosis and Inflammation?

      • Takashi Ito, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama

      Pages 193-202

   3. Coagulation, Inflammation, and Tissue Remodeling

      • Koji Suzuki, Tatsuya Hayashi, Osamu Taguchi, Esteban Gabazza

      Pages 203-210

   4. Structure and Function of the Endothelial Cell Protein C Receptor

      • Kenji Fukudome

      Pages 211-217

   5. New Aspects of Antiinflammatory Activity of Antithrombin: Molecular Mechanism(s) and Therapeutic Implications

      • Naoaki Harada, Kenji Okajima

      Pages 218-227

4. Platelets

   1. Front Matter

      Pages 229-229

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   2. Platelet Collagen Receptors

      • Stephanie M. Jung, Masaaki Moroi

      Pages 231-242

   3. Positive and Negative Regulation of Integrin Function

      • Yoshiaki Tomiyama, Masamichi Shiraga, Hirokazu Kashiwagi

      Pages 243-252

Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.

• Cardiovascular diseases
• Diabetes mellitus
• Thrombosis and hemostasis
• cardiovascular
• hypertension
• tissue

Aus den Rezensionen: “Das Werk ... ist gekennzeichnet von großer fachlicher Kompetenz und wissenschaftlicher Erfahrung der Autoren und Herausgeber. Die Hämostaseologie wird aufgrund neuester Erfahrungen modern und spannend dargestellt. ... Die fachliche Kompetenz der Autoren durchzieht sämtliche Texte dieses herausragenden Werkes über Thrombose und Hämostase. Wegen seiner Aktualität sollte es in keiner Bibliothek eines interessierten Hämostaseologen fehlen. Wir wünschen dem Werk eine weite Verbreitung in allen Fachkreisen der Hämostaseologie.“ (H. D. Bruhn, in: Hämastaseologie, January/2010, Issue 1, S. 42)

• Department of Pathology, Kyushu University, Fukuoka, Japan

  Kenzo Tanaka

• Department of Biochemistry, University of Washington, Seattle, USA

  Earl W. Davie

• School of Medicine, Internal Medicine, Keio University, Tokyo, Japan

  Yasuo Ikeda

• Department of Biology, Kyushu University, Fukuoka, Japan

  Sadaaki Iwanaga

• Department of Medicine, Nagoya University, Nagoya, Japan

  Hidehiko Saito

• Pathophysiological and Experimental Division, Department of Pathology, Kyushu University, Fukuoka, Japan

  Katsuo Sueishi

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