Th 17 Cells: Role in Inflammation and Autoimmune Disease

1. Front Matter

   Pages i-xii

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2. Introduction

   1. Introduction

      • Franco Di Padova, Bernhard Ryffel, Valérie Quesniaux

      Pages 1-9

3. Discovery and IL-17 family

   1. Front Matter

      Pages 11-11

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   2. IL-22 and IL-17: Common and different properties

      • Robert Sabat, Katrin Witte, Kerstin Wolk

      Pages 13-38

   3. Other sources of IL-17: Invariant natural killer T cells

      • Marie-Laure Miche, Maria C. Leite-de-Moraes

      Pages 39-48

   4. Contributions of IL-22 to Th17 responses: Repairing and protecting peripheral tissues

      • Jean-Christophe Renauld, Laure Dumoutier

      Pages 49-60

   5. Retinoic acid in mucosal immune-regulation

      • Daniel Mucida, Hilde Cheroutre

      Pages 61-68

   6. IL-25, another promoter of allergy

      • Pornpimon Angkasekwinai, Chen Dong

      Pages 69-80

4. Experimental models of disease

   1. Front Matter

      Pages 81-81

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   2. Critical role of IL-17 in experimental arthritis

      • Marije I. Koenders, Wim B. van den Berg

      Pages 83-94

   3. Dual role of IL-17 in allergic asthma

      • Bruno Schnyder, Silvia Schnyder-Candrian

      Pages 95-104

   4. Contribution of IL-17 to the pulmonary inflammatory response

      • Isabelle Couillin, Pamela Gasse, Francois Huaux, Silvia Schnyder-Candrian, Bruno Schnyder, François Erard et al.

      Pages 105-113

   5. The role of IL-17 in experimental autoimmune myocarditis

      • Alan Valaperti, Urs Eriksson

      Pages 115-126

   6. Th17 cells in organ transplantation

      • Ye Chen, Kathryn J. Wood

      Pages 127-132

5. Role of IL-23/IL-17 in infection and tumor control

   1. Front Matter

      Pages 133-133

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   2. Is IL-17 required to control tuberculosis?

      • Andrea M. Cooper

      Pages 135-147

   3. IL-17 and mucosal host defense

      • Shabaana A. Khader, Jay K. Kolls

      Pages 149-159

   4. IL-23 orchestrates the switch from tumor immune surveillance to tumor-promoting inflammation

      • Martin Oft

      Pages 161-172

6. IL-17 in clinical autoimmune disease

   1. Front Matter

      Pages 173-173

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   2. IL-17 and Th17 cells in rheumatoid arthritis

      • Pierre Miossec

      Pages 175-184

The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on the potential role of Th17 in inflammatory diseases. Experimental studies confirmed that IL-17A is induced and is critical for the development of allergic lung inflammation, arthritis, bacterial sepsis, experimental allergic encephalomyelitis and myocarditis, as well as other inflammatory con- tions including organ transplantation. The role of IL-17F and IL-22 is still poorly defined and is only slowly emerging.

• Arthritis
• Autoimmune diseases
• Immunity
• Promoter
• allergic disorders
• asthma
• autoimmune disease
• immune surveillance
• infectious
• inflammation
• inflammatory response
• tissue
• transplantation
• tuberculosis
• tumor control
• infectious diseases

From the reviews:

“This very interesting volume contains 18 reviews grouped in five chapters and presents the accumulated knowledge related to the IL-17 cytokines, a novel family of cytokines that defines a new effector T cell, the Th17 cell, and extends the Th1-Th2 paradigm. … This multi-authors volume is an exciting and rewarding reading for scientists and medical doctors exploring novel mechanisms of inflammation and therapy.” (Mihaela Trif, Romanian Journal of Biochemistry, Vol. 47 (2), 2010)

• Molecular Immunology and Embryology, University of Orléans and CNRS UMR6218, Orléans, France

  Valérie Quesniaux, Bernhard Ryffel

• Novartis Institutes for Biomedical Research, NIBR WSJ 386-906, Basel, Switzerland

  Franco Padova

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