Overview
- Provides new advances regarding the involvement of MMPs in inflammatory diseases
- Written by leading experts in the field
- International authorship
Part of the book series: Progress in Inflammation Research (PIR)
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
Matrix metalloproteinases (MMPs) are proteolytic enzymes believed to be involved in many physiological and pathological processes associated with inflammatory reactions. MMP synthesis and functions are regulated by three major mechanisms including transcriptional activation, post-transcriptional processing, and control of activity by tissue inhibitors of metalloproteinases (TIMPs). Many cell types have been identified as producers of MMPs and TIMPs in a context of inflammatory processes. MMPs are involved in numerous inflammatory diseases, including respiratory, cardiovascular and central nervous system pathologies.
This volume presents new advances in the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs provides new insights in the relationship between activation of inflammatory cells and tissue remodelling and advises new therapeutic possibilities for the treatment of inflammatory diseases.
Editors and Affiliations
Bibliographic Information
Book Title: Matrix Metalloproteinases in Tissue Remodelling and Inflammation
Editors: Vincent Lagente, Elisabeth Boichot
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-7643-8585-9
Publisher: Birkhäuser Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Birkhäuser Basel 2008
Hardcover ISBN: 978-3-7643-8584-2Published: 18 September 2008
eBook ISBN: 978-3-7643-8585-9Published: 07 November 2008
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XI, 168
Number of Illustrations: 7 b/w illustrations
Topics: Immunology, Pneumology/Respiratory System, Infectious Diseases, Pharmacology/Toxicology, Cell Biology