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Complement and Kidney Disease

  • Book
  • © 2006

Overview

Editors:
  1. Peter F. Zipfel

    1. Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany

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  • Role of genetic mutations in regulator proteins
  • New therapies in human kidney diseases
  • Prof. Zipfel is a well renowned scientist in this area of research
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Inflammation Research (PIR)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvi
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  2. The complement system in renal diseases

    • Momir Macanovic, Peter Lachmann
    Pages 1-18

  3. Complement in renal transplantation

    • Wuding Zhou, Steven H. Sacks
    Pages 19-35

  4. C1q and the glomerulonephritides: therapeutic approaches for the treatment of complement-mediated kidney diseases

    • Stefan P. Berger, Tom W.L. Groeneveld, Anja Roos, Mohamed R. Daha
    Pages 37-47

  5. Complement deficient mice as model systems for kidney diseases

    • Joshua M. Thurman, V. Michael Holers
    Pages 49-63

  6. Non-Shiga toxin-associated hemolytic uremic syndrome

    • Marina Noris1, Giuseppe Remuzzi
    Pages 65-83

  7. Role of complement and Factor H in hemolytic uremic syndrome

    • Christine Skerka, Mihály Józsi
    Pages 85-109

  8. Genetic testing in atypical HUS and the role of membrane cofactor protein (MCP; CD46) and Factor I

    • Timothy H.J. Goodship, Véronique Frémeaux-Bacchi, John P. Atkinson
    Pages 111-127

  9. Towards a new classification of hemolytic uremic syndrome

    • Maren Salzmann, Michael Hoffmann, Gisa Schluh, Peter Riegler, Markus Cybulla, Hartmut P.H. Neumann
    Pages 129-148

  10. Therapeutic strategies for atypical and recurrent hemolytic uremic syndromes (HUS)

    • Reinhard Würzner, Lothar B. Zimmerhackl
    Pages 149-163

  11. Complement defects in children which result in kidney diseases: diagnosis and therapy

    • Christoph Licht, Bernd Hoppe
    Pages 165-197

  12. The role of complement in membranoproliferative glomerulonephritis

    • Peter F. Zipfel, Richard J.H. Smith, Stefan Heinen
    Pages 199-221

  13. The experience of a patient advocacy group

    • Pearl L. Lewis
    Pages 223-231

  14. Back Matter

    Pages 233-238
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Keywords

About this book

It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.

Editors and Affiliations

  • Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany

    Peter F. Zipfel

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