Editors:
- Role of genetic mutations in regulator proteins
- New therapies in human kidney diseases
- Prof. Zipfel is a well renowned scientist in this area of research
- Includes supplementary material: sn.pub/extras
Part of the book series: Progress in Inflammation Research (PIR)
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (12 chapters)
-
Front Matter
-
Back Matter
About this book
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Editors and Affiliations
-
Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
Peter F. Zipfel
Bibliographic Information
Book Title: Complement and Kidney Disease
Editors: Peter F. Zipfel
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/3-7643-7428-4
Publisher: Birkhäuser Basel
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Birkhäuser Basel 2006
Hardcover ISBN: 978-3-7643-7166-1
eBook ISBN: 978-3-7643-7428-0
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XVI, 236
Topics: Immunology, Cell Biology, Nephrology, Human Physiology, Internal Medicine, Medical Microbiology