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Melanoma Development

Molecular Biology, Genetics and Clinical Application

  • Book
  • © 2011

Overview

Editors:
  1. Anja Bosserhoff

    1. , Molecular Pathology, Institute of Pathololgy, Regensburg, Germany

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  • Clearly structured book presenting all relevant aspects of malignant melanoma from basic research to therapeutic concepts

  • Excellent authors contribute to this book

  • Nowhere else a book focussing on both, molecular mechanism and therapeutical targets can be found

  • Firstly presents the newly emerging area of melanoma research which leads to targeted therapies

  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Introduction

    • Anja Bosserhoff, Luigi Strizzi
    Pages 1-5

  3. Epidermal Melanocytes: Regulation of Their Survival, Proliferation, and Function in Human Skin

    • Zalfa A. Abdel-Malek, Viki B. Swope
    Pages 7-33

  4. Melanoma Epidemiology

    • Marianne Berwick
    Pages 35-55

  5. Melanoma Genetics and Genomics

    • Göran Jönsson, Hensin Tsao
    Pages 57-77

  6. Transcriptional Regulation in Melanoma

    • Satoru Yokoyama, David E. Fisher
    Pages 79-103

  7. miRNAs in Malignant Melanoma

    • Daniel W. Mueller, Anja Bosserhoff
    Pages 105-136

  8. Altered Signal Transduction Pathways in Melanoma

    • Eric Lau, Ze’ev A. Ronai
    Pages 137-163

  9. Proteases in Melanoma

    • Paola Zigrino, Cornelia Mauch
    Pages 165-179

  10. Cell–Cell and Cell–Matrix Contacts in Melanoma and the Tumor Microenvironment

    • Silke Kuphal, Nikolas K. Haass
    Pages 181-215

  11. Regulation of Apoptosis in Melanoma Cells: Targets for Therapeutic Strategies

    • Jürgen Eberle, Lothar F. Fecker
    Pages 217-233

  12. Senescence

    • Helen Rizos, Lyndee L. Scurr
    Pages 235-254

  13. Melanoma Stem Cells

    • Tobias Schatton, Markus H. Frank
    Pages 255-279

  14. Lessons from Embryogenesis

    • Luigi Strizzi, Katharine M. Hardy, Elisabeth A. Seftor, Naira V. Margaryan, Dawn A. Kirschmann, Gina T. Kirsammer et al.
    Pages 281-296

  15. Tumor Microenvironment for Melanoma Cells

    • Gao Zhang, Meenhard Herlyn
    Pages 297-307

  16. Melanoma Model Systems

    • Birgit Schittek, Thomas Tüting
    Pages 309-335

  17. New Therapeutic Approaches in Signaling

    • Keith T. Flaherty
    Pages 337-357

  18. Immunotherapy of Melanoma: A New Era

    • Alexander M. M. Eggermont, Caroline Robert, Dirk Schadendorf
    Pages 359-372

  19. Back Matter

    Pages 373-373
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Keywords

About this book

The book provides comprehensive insights into molecular changes in malignant melanoma. The general mechanisms of melanoma growth and development are described, as well as new research findings. Our current knowledge on the molecules involved in cell transformation and tumor progression will soon lead to sophisticated, targeted therapies. Recent studies with targeted b-RAF inhibitors have given us grounds to hope that these therapies will be successful. Melanoma Development- Molecular Biology, Genetics and Clinical Application aims to contribute to this knowledge. Summarizing the newest data and presenting upcoming research areas in the field, the book will be of great interest to basic researchers and physicians working in the important fields of melanoma, cancer research, therapy and dermatology.

Editors and Affiliations

  • , Molecular Pathology, Institute of Pathololgy, Regensburg, Germany

    Anja Bosserhoff

About the editor

Anja Bosserhoff studied biology at the University of Bielefeld, Germany. She completed her PhD at the Department of Dermatology, University of Regensburg, Germany, in 1995. Between 1995 and 1998 she received her postdoctoral education at the Institute for Pathology, University of Regensburg. In 1998 and 1999 she served as assistant researcher at the Institute for Pathology in Regensburg and at the Rhine-Wesfalia-Technical –University (RWTH) in Aachen, Germany, respectively. In 2000 she became Professor in general and molecular pathology of the cell at the University of Aachen (Habilitation). Since 2002 Anja Bosserhoff has been Full Professor at the Institute for Pathology and Head of the Division of Molecular Pathology in Regensburg. She has published more than 150 papers in international renowned high impact journals, contributed to several book projects and written several review articles. She received various national and international research awards, among which the “Deutscher Hautkrebspreis” in 2007.

Bibliographic Information

  • Book Title: Melanoma Development

  • Book Subtitle: Molecular Biology, Genetics and Clinical Application

  • Editors: Anja Bosserhoff

  • DOI: https://doi.org/10.1007/978-3-7091-0371-5

  • Publisher: Springer Vienna

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag/Wien 2011

  • eBook ISBN: 978-3-7091-0371-5Published: 24 June 2011

  • Edition Number: 1

  • Number of Pages: XI, 376

  • Topics: Cancer Research

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