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Blistering Diseases

Clinical Features, Pathogenesis, Treatment

  • Book
  • © 2015

Overview

Editors:
  1. Dédée F. Murrell

    1. Department of Dermatology, St George Hospital, University of New South Wales, Sydney, Australia

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  • Describes all the dermatologist needs to know about blistering diseases

  • Presents information in a readily intelligible and accessible way

  • Includes algorithms for treatment and for testing and monitoring

  • Offers an ideal “one-stop information shop” for specialists outside of dermatology

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Table of contents (76 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Pathogenesis

    1. Front Matter

      Pages 1-1
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    2. Biology of the Basement Membrane Zone

      • Sana Hashmi, M. Peter Marinkovich
      Pages 3-20

    3. The Immune System in Normal Skin and in AIBD

      • Karlin Karlmark, Rüdiger Eming
      Pages 21-33

    4. Keratins and Their Role in EB Simplex

      • Mor Miodovnik, Eli Sprecher
      Pages 35-47

    5. Desmosomal Proteins and Their Role in Epidermolysis Bullosa

      • John A. McGrath
      Pages 49-54

    6. Desmosomal Proteins as Autoantigens in Pemphigus

      • Flor Evangelista, Donna A. Culton, Luis A. Diaz
      Pages 55-65

    7. Collagen XVII and Its Role in Junctional Epidermolysis Bullosa

      • Cristina Has, Leena Bruckner-Tuderman
      Pages 67-75

    8. Plectin in Epidermolysis Bullosa and Autoimmune, Bullous Diseases

      • Johann W. Bauer, Alfred Klausegger
      Pages 77-84

    9. Integrins A6 and B4 and Their Role in Junctional Epidermolysis Bullosa and Recessive Epidermolysis Bullosa Simplex

      • Ningning Dang, Dédée F. Murrell
      Pages 85-90

    10. Laminin 332 in Junctional Epidermolysis and as an Autoantigen in Mucous Membrane Pemphigoid

      • Patricia Rousselle, Anna Michopoulou
      Pages 91-102

    11. Kindlin-1 and Its Role in Kindler Syndrome

      • Cristina Has
      Pages 103-110

    12. COL7A1 and Its Role in Dystrophic Epidermolysis Bullosa

      • Ningning Dang, Dédée F. Murrell
      Pages 111-120

    13. Pathogenesis of Epidermolysis Bullosa Acquisita

      • Ralf J. Ludwig, Detlef Zillikens
      Pages 121-130

    14. Genetic and Environmental Risk Factors of Autoimmune Bullous Diseases

      • Enno Schmidt, Luca Borradori, Eli Sprecher, Branka Marinovic, Animesh A. Sinha, Pascal Joly
      Pages 131-139

    15. Apoptosis and Signaling in Bullous Diseases: Pemphigus

      • David S. Rubenstein, Carlo Pincelli
      Pages 141-152

  3. Diagnostic Tests

    1. Front Matter

      Pages 153-153
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    2. How to Take a Skin Biopsy Correctly to Diagnose Epidermolysis Bullosa and Autoimmune Bullous Diseases

      • Johanna Pauline H. Lazo-Dizon, Dédée F. Murrell
      Pages 155-159

    3. Histological and Immunofluorescence Diagnosis of Autoimmune Blistering Diseases

      • Jose M. Mascaró Jr.
      Pages 161-191

    4. ELISA Testing and Immunoblotting

      • Daisuke Tsuruta, Takashi Hashimoto
      Pages 193-201
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Keywords

About this book

This book is a comprehensive compendium of current knowledge on inherited and autoimmune blistering diseases that relates advances in our understanding of the pathogenetic mechanisms to management of the individual diseases. The aim is to provide a detailed reference for dermatologists who care for patients with these conditions and a useful “one-stop information shop” for specialists outside of dermatology. The book opens by describing the structure and biology of the epidermis and basement membrane zone and discussing the genes and proteins that are targets for mutations and autoantibodies. The role of the various diagnostic tests is explained, and clinical manifestations of the specific diseases are presented with the aid of many high-quality illustrations. The forms of treatment appropriate in specific conditions are then described in depth, with coverage of dressings, drugs, surgical procedures, gene therapy, and other novel approaches. Helpful algorithms are included both for testing and monitoring and for treatment.

Reviews

“This is a true textbook, presenting a thorough and well-organized discussion of a complex and often difficult area of dermatology. It presents the most complete discussion of blistering diseases I have ever encountered. And it manages to organize this wealth of information clearly, so the book can be used for quick reference as well as for complete reading. This is a valuable reference for any practicing dermatologist, training resident, or researcher in this field.” (Kathleen E. Kramer, Doody's Book Reviews, September, 2016)

Editors and Affiliations

  • Department of Dermatology, St George Hospital, University of New South Wales, Sydney, Australia

    Dédée F. Murrell

Bibliographic Information

  • Book Title: Blistering Diseases

  • Book Subtitle: Clinical Features, Pathogenesis, Treatment

  • Editors: Dédée F. Murrell

  • DOI: https://doi.org/10.1007/978-3-662-45698-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Hardcover ISBN: 978-3-662-45697-2Published: 17 March 2015

  • Softcover ISBN: 978-3-662-50785-8Published: 06 October 2016

  • eBook ISBN: 978-3-662-45698-9Published: 05 March 2015

  • Edition Number: 1

  • Number of Pages: XXI, 752

  • Number of Illustrations: 35 b/w illustrations, 170 illustrations in colour

  • Topics: Dermatology, Pathology, Pediatrics, Internal Medicine

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