Overview
- Discusses therapeutic potential of biased ligands of G protein-coupled receptors
- Describes the molecular mechanisms and therapeutic implications of arrestin-mediated signaling
- Discusses the potential of reengineered signaling proteins for gene therapy
- Includes supplementary material: sn.pub/extras
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 219)
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Table of contents (22 chapters)
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Front Matter
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Arrestins and Regulation of G Protein-Coupled Receptors
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Front Matter
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Arrestin Interactions with Non-receptor Partners and Roles in Cell Signaling
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Front Matter
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Keywords
About this book
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
Editors and Affiliations
Bibliographic Information
Book Title: Arrestins - Pharmacology and Therapeutic Potential
Editors: Vsevolod V. Gurevich
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-642-41199-1
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-642-41198-4Published: 16 December 2013
Softcover ISBN: 978-3-662-52299-8Published: 23 August 2016
eBook ISBN: 978-3-642-41199-1Published: 29 November 2013
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: VIII, 447
Number of Illustrations: 11 b/w illustrations, 42 illustrations in colour
Topics: Pharmacology/Toxicology, Biochemistry, general, Protein Structure, Gene Therapy, Cell Physiology, Receptors