Overview
- Examines the latest developments in antibacterial research and drug design
- Integrates basic and clinical aspects
- Written by international experts
- Includes supplementary material: sn.pub/extras
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Table of contents (17 chapters)
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Front Matter
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Current Trends in Antibiotics, Pathogens and Medical Needs
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Front Matter
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Families of Novel Candidates and Conventional Antibiotics
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Front Matter
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Keywords
About this book
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens.
This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
Editors and Affiliations
Bibliographic Information
Book Title: Antimicrobials
Book Subtitle: New and Old Molecules in the Fight Against Multi-resistant Bacteria
Editors: Flavia Marinelli, Olga Genilloud
DOI: https://doi.org/10.1007/978-3-642-39968-8
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2014
Hardcover ISBN: 978-3-642-39967-1Published: 15 October 2013
Softcover ISBN: 978-3-662-50908-1Published: 23 August 2016
eBook ISBN: 978-3-642-39968-8Published: 04 October 2013
Edition Number: 1
Number of Pages: VIII, 364
Number of Illustrations: 61 b/w illustrations, 10 illustrations in colour
Topics: Medical Microbiology, Drug Resistance, Infectious Diseases, Applied Microbiology