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Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology

  • Book
  • © 2008

Overview

Editors:
  1. Bruce Beutler

    1. Department of Immunology, Scripps Research Institute, La Jolla, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 321)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  3. Self-Reactivity

    1. Scurfy, the Foxp3 Locus, and the Molecular Basis of Peripheral Tolerance

      • M. W. Appleby, F. Ramsdell
      Pages 151-168

    2. Fevers, Genes, and Innate Immunity

      • J. G. Ryan, D. L. Kastner
      Pages 169-184

    3. Itchy Mice: The Identification of a New Pathway for the Development of Autoimmunity

      • L. E. Matesic, N. G. Copeland, N. A. Jenkins
      Pages 185-200

    4. TIM Gene Family and Their Role in Atopic Diseases

      • D. T. Umetsu, S. E. Umetsu, G. J. Freeman, R. H. DeKruyff
      Pages 201-215

  4. Back Matter

    Pages 217-220
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Keywords

About this book

This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. “What has C. elegans to do with me?” the questioning might go. “It doesn’t even have lymphocytes. ” Such skeptics may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind. So I would like to introduce the topic with a few words about the power of genetics, and why it has contributed so much to immunology, and to bi- ogy in general. Genetics, as the word is used here, is not merely the science of heredity, but much more than that. It is the science of exceptions: the science that takes note of heritable variation and seeks to explain it at the most fundamental level.

Editors and Affiliations

  • Department of Immunology, Scripps Research Institute, La Jolla, USA

    Bruce Beutler

Bibliographic Information

  • Book Title: Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology

  • Editors: Bruce Beutler

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-540-75203-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008

  • Hardcover ISBN: 978-3-540-75202-8Published: 21 July 2008

  • Softcover ISBN: 978-3-642-09445-3Published: 19 November 2010

  • eBook ISBN: 978-3-540-75203-5Published: 20 June 2008

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIII, 220

  • Topics: Immunology

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