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Biophysics of Infection

  • Book
  • © 2016

Overview

Editors:
  1. Mark C. Leake

    1. Biological Physical Sciences Institute, University of York, York, United Kingdom

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  • Provides detailed reviews and protocols written by leading international experts
  • Explores basic molecular biological aspects as well as physical methods and mathematical analysis
  • Offers up-to-date information on infection processes investigated using modern biophysical techniques
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 915)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The Biophysics of Infection

    • Mark C. Leake
    Pages 1-3

  3. Single-Molecule Observation of DNA Replication Repair Pathways in E. coli

    • Adam J. M. Wollman, Aisha H. Syeda, Peter McGlynn, Mark C. Leake
    Pages 5-16

  4. Investigating the Swimming of Microbial Pathogens Using Digital Holography

    • K. L. Thornton, R. C. Findlay, P. B. Walrad, L. G. Wilson
    Pages 17-32

  5. What Is the ‘Minimum Inhibitory Concentration’ (MIC) of Pexiganan Acting on Escherichia coli?—A Cautionary Case Study

    • Alys K. Jepson, Jana Schwarz-Linek, Lloyd Ryan, Maxim G. Ryadnov, Wilson C. K. Poon
    Pages 33-48

  6. Evolution of Drug Resistance in Bacteria

    • B. Waclaw
    Pages 49-67

  7. Using Biophysics to Monitor the Essential Protonmotive Force in Bacteria

    • Mei-Ting Chen, Chien-Jung Lo
    Pages 69-79

  8. The Type I Restriction Enzymes as Barriers to Horizontal Gene Transfer: Determination of the DNA Target Sequences Recognised by Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complexes 133/ST771 and 398

    • Kai Chen, Augoustinos S. Stephanou, Gareth A. Roberts, John H. White, Laurie P. Cooper, Patrick J. Houston et al.
    Pages 81-97

  9. Biomechanical Analysis of Infectious Biofilms

    • David Head
    Pages 99-114

  10. Designing a Single-Molecule Biophysics Tool for Characterising DNA Damage for Techniques that Kill Infectious Pathogens Through DNA Damage Effects

    • Helen Miller, Adam J. M. Wollman, Mark C. Leake
    Pages 115-127

  11. Bacterial Surfaces: Front Lines in Host–Pathogen Interaction

    • Jane E. King, Ian S. Roberts
    Pages 129-156

  12. Biophysical Approaches to Bacterial Gene Regulation by Riboswitches

    • Cibran Perez-Gonzalez, Jonathan P. Grondin, Daniel A. Lafontaine, J. Carlos Penedo
    Pages 157-191

  13. Bugs on a Slippery Plane

    • Dmitri O. Pushkin, Martin A. Bees
    Pages 193-205

  14. Transcription Regulation and Membrane Stress Management in Enterobacterial Pathogens

    • Nan Zhang, Goran Jovanovic, Christopher McDonald, Oscar Ces, Xiaodong Zhang, Martin Buck
    Pages 207-230

  15. How Biophysics May Help Us Understand the Flagellar Motor of Bacteria Which Cause Infections

    • Matthew A. B. Baker
    Pages 231-243

  16. Mechanics of Bacterial Cells and Initial Surface Colonisation

    • Sebastian Aguayo, Laurent Bozec
    Pages 245-260

  17. Neutron Reflectivity as a Tool for Physics-Based Studies of Model Bacterial Membranes

    • Robert D. Barker, Laura E. McKinley, Simon Titmuss
    Pages 261-282

  18. Mechanisms of Salmonella Typhi Host Restriction

    • Stefania Spanò
    Pages 283-294

  19. Insights into Biological Complexity from Simple Foundations

    • L. Albergante, D. Liu, S. Palmer, T. J. Newman
    Pages 295-305

  20. Force Spectroscopy in Studying Infection

    • Zhaokun Zhou, Mark C. Leake
    Pages 307-327
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Keywords

About this book

This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcus aureus; infectious and bacterial pathogen biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bacterial gene regulation by riboswitches; transcription regulation in enterobacterial pathogens; the bacterial flagellar motor; initial surface colonization by bacteria; Salmonella Typhi host restrictions; as well as monitoring proton motive force in bacteria; microbial pathogens using digital holography; mathematical modelling of microbial pathogen motility; neutron reflectivity in studying bacterial membranes; force spectroscopy in studying infection and 4D multi-photon imaging to investigate immune responses. The focus is on the development and application of complex techniques and protocols at the interface of life sciences and physics, which increase the physiological relevance of biophysical investigations.




Editors and Affiliations

  • Biological Physical Sciences Institute, University of York, York, United Kingdom

    Mark C. Leake

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