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Cardiomyocytes – Active Players in Cardiac Disease

  • Book
  • © 2016

Overview

Editors:
  1. Klaus-Dieter Schlüter

    1. Institute of Physiology, Justus-Liebig-Universität Giessen, Giessen, Germany

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  • Provides a comprehensive insight into cardiomyocyte function and dysfunction

  • Readers will learn about common techniques and analysis

  • Experts depict regeneration capacities and possibilities of cardiac protection

  • Gives a broad overview on cardiomyocyte biology

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xv
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  2. Cardiomyocytes: Function and Regeneration

    1. Front Matter

      Pages 1-1
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    2. Ways to Study the Biology of Cardiomyocytes

      • Klaus-Dieter Schlüter
      Pages 3-23

    3. Cardiomyocytes: Function and Regeneration

      • Marten Szibor
      Pages 25-65

    4. Excitation–Contraction Coupling of Cardiomyocytes

      • Jens Kockskämper
      Pages 67-96

    5. Cardiac Metabolism and Energetic Control

      • Susanne Rohrbach, Bernd Niemann
      Pages 97-134

    6. Endogenous Mechanisms for Regulating Myocardial Contractility

      • Rolf Schreckenberg
      Pages 135-163

  3. Cardiomyocytes in Ageing, Disease, and Protection

    1. Front Matter

      Pages 165-165
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    2. Growth Regulation of Cardiomyocytes: Control of Cell Size and Its Role in Cardiac Hypertrophy

      • Klaus-Dieter Schlüter
      Pages 167-189

    3. Protein Degradation in Cardiomyocytes: Target Proteins and Clinical Consequences

      • Oliver Drews
      Pages 191-222

    4. Ischemia and Reperfusion

      • Jacqueline Heger
      Pages 223-245

    5. Mechanisms of Cardiac Cell Death

      • Gerhild Euler
      Pages 247-265

    6. Oxidative Stress and Nitrosative Stress

      • Rainer Schulz, Fabio Di Lisa
      Pages 267-278
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Keywords

About this book

This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine.

The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.

 

Editors and Affiliations

  • Institute of Physiology, Justus-Liebig-Universität Giessen, Giessen, Germany

    Klaus-Dieter Schlüter

About the editor

Prof. Dr. Klaus-Dieter Schlüter Institute of Physiology JLU Giessen Giessen, Germany

Bibliographic Information

  • Book Title: Cardiomyocytes – Active Players in Cardiac Disease

  • Editors: Klaus-Dieter Schlüter

  • DOI: https://doi.org/10.1007/978-3-319-31251-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-31249-1Published: 07 July 2016

  • Softcover ISBN: 978-3-319-80999-1Published: 30 May 2018

  • eBook ISBN: 978-3-319-31251-4Published: 28 June 2016

  • Edition Number: 1

  • Number of Pages: XV, 278

  • Number of Illustrations: 27 b/w illustrations, 13 illustrations in colour

  • Topics: Cell Biology, Cardiology, Human Physiology, Pharmaceutical Sciences/Technology

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