Overview
- Introduces new diagnostic immunological methods for diabetic diseases as potential companion diagnostics, developed in collaboration with leading universities, medical schools, and industrial experts
- Reviews progress in understanding of new inflammatory pathways in diabetic diseases
- Provides new methodologies for biomarker discovery
Part of the book series: Progress in Inflammation Research (PIR)
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Table of contents (11 chapters)
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Front Matter
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Introduction
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Front Matter
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Impact of Complement on Diabetic Disease
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Front Matter
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Role of C Terminal Fragment of Adiponectin Receptor in Inhibition of Insulin Degradation
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Front Matter
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Uristatin Assay for Prediction of Renal and Other Clinical Events
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Front Matter
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Summary
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Front Matter
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Back Matter
Keywords
About this book
This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease, and identifies new diagnostic immunological methods that offer potential companion diagnostics for diabetic diseases. New methods in proteomics, mass spectroscopy, immunological assay design, measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways. Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases. The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance, metabolic syndrome, nephritis and other diabetic inflammatory conditions, and is the first to describe the impact of novel adipokines, protease inhibitors and complement markers. By presenting new methodologies for biomarker discovery, it provides a valuable resource for researchers studying clinical diagnosis, drug development, bio-analytical chemistry, proteomics and biochemistry. It is also useful for those conducting clinical and biological studies for targeted drug development. The methodologies and approaches can be applied to other markers, and the information will be helpful in the preparation of research grant applications.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Inflammatory Pathways in Diabetes
Book Subtitle: Biomarkers and Clinical Correlates
Editors: Michael Pugia
Series Title: Progress in Inflammation Research
DOI: https://doi.org/10.1007/978-3-319-21927-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-21926-4Published: 30 October 2015
Softcover ISBN: 978-3-319-37281-5Published: 29 October 2016
eBook ISBN: 978-3-319-21927-1Published: 20 October 2015
Series ISSN: 1422-7746
Series E-ISSN: 2296-4525
Edition Number: 1
Number of Pages: XVI, 219
Number of Illustrations: 15 b/w illustrations, 18 illustrations in colour
Topics: Immunology, Diabetes, Pharmacology/Toxicology, Metabolic Diseases, Biochemistry, general