Editors:
- Provides compilation of major experimental mouse model systems for future preclinical research on energy balance and cancer
- Identifies how models are further enhanced by technology to identify DNA sequence changes that result in cancer driver genes in humans
- Explores models under the scope of genetic, epigenetic, and environmental modifiers such as diet, exercise, diurnal rhythm and others on cancer
Part of the book series: Energy Balance and Cancer (EBAC, volume 10)
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Table of contents (13 chapters)
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Front Matter
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Back Matter
About this book
This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment.
The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Editors and Affiliations
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Center for Science, Health & Society, Case Western Reserve University School of Medicine, Cleveland, USA
Nathan A. Berger
About the editor
Bibliographic Information
Book Title: Murine Models, Energy Balance, and Cancer
Editors: Nathan A. Berger
Series Title: Energy Balance and Cancer
DOI: https://doi.org/10.1007/978-3-319-16733-6
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-16732-9Published: 01 July 2015
Softcover ISBN: 978-3-319-38355-2Published: 17 October 2016
eBook ISBN: 978-3-319-16733-6Published: 19 June 2015
Series ISSN: 2199-2622
Series E-ISSN: 2199-2630
Edition Number: 1
Number of Pages: XV, 295
Number of Illustrations: 4 b/w illustrations, 36 illustrations in colour
Topics: Cancer Research, Animal Models, Laboratory Medicine