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Pre-Analytics of Pathological Specimens in Oncology

  • Book
  • © 2015

Overview

Editors:
  1. Manfred Dietel

    1. Institute of Pathology, Charité University Medicine, Berlin, Germany

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  2. Christian Wittekind

    1. Institute of Pathology, University Hospital Leipzig, Leipzig, Germany

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  3. Gianni Bussolati

    1. University of Turin Institute of Pathology, Turin, Italy

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  4. Moritz Winterfeld

    1. Institute of Pathology, Charité University Medicine, Berlin, Germany

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  • Offers guidance in how to optimize the pre-analytical handling of tissue and improve diagnostic quality
  • Discusses the importance of cold ischemia time
  • Examines the value of vacuum-based preservation and two-temperature fixation
  • Includes supplementary material: sn.pub/extras

Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 199)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-vi
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  2. The Pre-analytical Phase in Surgical Pathology

    • Gianni Bussolati, Laura Annaratone, Francesca Maletta
    Pages 1-13

  3. Histologic Validation of Vacuum Sealed, Formalin-Free Tissue Preservation, and Transport System

    • Richard J. Zarbo
    Pages 15-26

  4. The Evolution of Pre-analytic Factors in Anatomic Pathology

    • Stephen M. Hewitt
    Pages 27-34

  5. Tissue Heterogeneity as a Pre-analytical Source of Variability

    • Giorgio Stanta
    Pages 35-43

  6. Standardized Processing of Native Tissue in Breast Pathology

    • M. E. Dämmrich, H. H. Kreipe
    Pages 45-53

  7. Short Formalin Fixation and Rapid Microwave Processing Do Not Affect HER2 Testing

    • Isabella Sassi, Francesca Invernizzi, Claudio Doglioni
    Pages 55-64

  8. Current Projects in Pre-analytics: Where to Go?

    • Anna Sapino, Laura Annaratone, Caterina Marchiò
    Pages 65-70

  9. Preanalytics in Lung Cancer

    • Arne Warth, Thomas Muley, Michael Meister, Wilko Weichert
    Pages 71-84

  10. RNA Quality in Fresh-Frozen Gastrointestinal Tumor Specimens—Experiences from the Tumor and Healthy Tissue Bank TU Dresden

    • Silke Zeugner, Thomas Mayr, Christian Zietz, Daniela E. Aust, Gustavo B. Baretton
    Pages 85-93

  11. Bone Marrow Work-up: Report of a Pilot Study

    • Ioannis Anagnostopoulos, Dido Lenze, Michael Hummel, Manfred Dietel, Korinna Jöhrens
    Pages 95-105

  12. Two-Temperature Formalin Fixation Preserves Activation States Efficiently

    • David Chafin
    Pages 107-117

  13. Towards the Lean lab: The Industry Challenge

    • Franco Visinoni
    Pages 119-133
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Keywords

About this book

This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.

Editors and Affiliations

  • Institute of Pathology, Charité University Medicine, Berlin, Germany

    Manfred Dietel, Moritz Winterfeld

  • Institute of Pathology, University Hospital Leipzig, Leipzig, Germany

    Christian Wittekind

  • University of Turin Institute of Pathology, Turin, Italy

    Gianni Bussolati

Bibliographic Information

  • Book Title: Pre-Analytics of Pathological Specimens in Oncology

  • Editors: Manfred Dietel, Christian Wittekind, Gianni Bussolati, Moritz Winterfeld

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-319-13957-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-13956-2Published: 10 March 2015

  • Softcover ISBN: 978-3-319-34982-4Published: 06 October 2016

  • eBook ISBN: 978-3-319-13957-9Published: 30 January 2015

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: VI, 133

  • Number of Illustrations: 4 b/w illustrations, 61 illustrations in colour

  • Topics: Oncology, Pathology, Surgery, Laboratory Medicine

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