Overview
- Editors:
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Geraldo A. Passos
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Department of Genetics, University of São Paulo, Ribeirão Preto, Brazil
First book to address transcriptomics in health and disease
Written by leading experts in the field
Useful for researchers in molecular biology, gene expression, human genetics, immunology, and genomics
Includes supplementary material: sn.pub/extras
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Table of contents (17 chapters)
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Front Matter
Pages i-xvii
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Basic Principles of the Transcriptome and Its Analysis
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- Amanda F. Assis, Ernna H. Oliveira, Paula B. Donate, Silvana Giuliatti, Catherine Nguyen, Geraldo A. Passos
Pages 3-48
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- Tainá Raiol, Daniel Paiva Agustinho, Kelly Cristina Rodrigues Simi, Calliandra Maria de Souza Silva, Maria Emilia Walter, Ildinete Silva-Pereira et al.
Pages 49-68
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- Patricia Severino, Elisa Napolitano Ferreira, Dirce Maria Carraro
Pages 69-78
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- Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Filipi Nascimento Silva, Luciano da Fontoura Costa
Pages 79-94
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- Bruno Dallagiovanna, Fabiola Holetz, Patricia Shigunov
Pages 95-107
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- Karina F. Bombonato-Prado, Adalberto L. Rosa, Paulo T. Oliveira, Janaína A. Dernowsek, Vanessa Fontana, Adriane F. Evangelista et al.
Pages 109-119
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Transcriptome in Disease
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Front Matter
Pages 121-121
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- Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Filipi Nascimento Silva, Luciano da Fontoura Costa, Magda Carneiro-Sampaio
Pages 123-136
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- Cristhianna V. A. Collares, Eduardo A. Donadi
Pages 137-159
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- Paula Takahashi, Danilo J. Xavier, Elza T. Sakamoto-Hojo
Pages 161-180
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- Adriane F. Evangelista, Marcia M. C. Marques
Pages 181-193
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- Renê Donizeti Ribeiro de Oliveira, Paulo Louzada-Júnior
Pages 195-209
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- Olga Martinez Ibañez, José Ricardo Jensen, Marcelo De Franco
Pages 211-226
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- Nalu T. A. Peres, Gabriela F. Persinoti, Elza A. S. Lang, Antonio Rossi, Nilce M. Martinez-Rossi
Pages 227-263
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- Patrícia Albuquerque, Hugo Costa Paes, Aldo Henrique Tavares, Larissa Fernandes, Anamélia Lorenzetti Bocca, Ildinete Silva-Pereira et al.
Pages 265-287
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- Rodrigo Ferracine Rodrigues, Rogério Silva Rosada, Thiago Malardo, Wendy Martin Rios, Celio Lopes Silva
Pages 289-310
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- Ludmila Rodrigues P. Ferreira, Edecio Cunha-Neto
Pages 311-325
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About this book
After sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it. The authors discuss the concept and use of gene expression signatures and transcriptional biomarkers in normal development and diseased tissues and organs. As the transcriptome changes depending on the pathology, there is also a focus on the variations in the gene expression in different diseases such as autoimmune, inflammation, cancer and infections. This book should be very useful for researchers in molecular biology focusing on gene expression, human genetics, immunology, and genomics.
Editors and Affiliations
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Department of Genetics, University of São Paulo, Ribeirão Preto, Brazil
Geraldo A. Passos
