Editors:
- Written by leading experts in the field
- Provides a comprehensive and up to date overview on sphingosine-1-phosphate signaling
- An invaluable source of information for both basic and clinical researchers
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 378)
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Table of contents (8 chapters)
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Front Matter
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Back Matter
About this book
This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
Editors and Affiliations
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Department of Immunology and Microbial Sciiences, The Scripps Research Institute, La Jolla, USA
Michael B. A. Oldstone
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Department of Chemical Physiology, The Scripps Research Institute, La Jolla, USA
Hugh Rosen
About the editors
Bibliographic Information
Book Title: Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
Editors: Michael B. A. Oldstone, Hugh Rosen
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-05879-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2014
Hardcover ISBN: 978-3-319-05878-8Published: 29 April 2014
Softcover ISBN: 978-3-319-37603-5Published: 23 August 2016
eBook ISBN: 978-3-319-05879-5Published: 11 April 2014
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 184
Number of Illustrations: 5 b/w illustrations, 22 illustrations in colour
Topics: Immunology, Virology, Infectious Diseases