Endothelial Dysfunction and Inflammation

1. Front Matter

   Pages i-xii

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2. Endothelial activation and dysfunction in sepsis

   • John M. Harlan

   Pages 1-13

3. Heterogeneity in responses of microvascular endothelial cells during inflammation

   • Grietje Molema

   Pages 15-35

4. Oxidative stress and endothelial dysfunction

   • Stephanie T. de Dios, Christopher G. Sobey, Grant R. Drummond

   Pages 37-64

5. Post-translational regulation of eNOS activity in inflammation

   • Fanny Desjardins, Jean-Philippe Gratton

   Pages 65-80

6. Endothelial dysfunction in pulmonary hypertension

   • Dominique Yelle, Lakshmi Kugathasan, Robin E. MacLaren, Duncan J. Stewart

   Pages 81-102

7. Endothelial dysfunction in systemic hypertension

   • Carol Yu, Arpeeta Sharma, Andy Trane, Pascal Bernatchez

   Pages 103-117

8. Sphingosine-1-phosphate as a mediator of endothelial dysfunction during inflammation

   • Bodo Levkau

   Pages 119-135

9. Dissecting TNF-TNFR1/TNFR2 signaling pathways in vasculature

   • Wang Min, Ting Wan, Yan Luo

   Pages 137-159

10. AGE-RAGE signalling in endothelial dysfunction and atherosclerosis in diabetes

    • Anna M. D. Watson, Aino Soro-Paavonen, Karin A. Jandeleit-Dahm

    Pages 161-174

11. Regional predisposition to atherosclerosis – An interplay between local hemodynamics, endothelial cells and resident intimal dendritic cells

    • Jenny Jongstra-Bilen, Myron I. Cybulsky

    Pages 175-188

12. Inflammation and endothelial dysfunction with aging

    • Mary K. Y. Lee, Paul M. Vanhoutte

    Pages 189-200

13. Clinical approaches to assess endothelial function in vivo

    • Elizabeth A. Ellins, Julian P. Halcox

    Pages 201-217

14. Therapeutic approaches towards targeting endothelial dysfunction

    • John H. Boyd, Keith R. Walley

    Pages 219-230

15. Back Matter

    Pages 231-236

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Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

• Activation
• Atherosclerosis
• Endothelial Dysfunction
• Hypertension
• Inflammation
• Nitric oxide
• Oxidative stress
• Sepsis
• Vascular diseases
• regulation

• BC Cancer Research Center, Vancouver, Canada

  Shauna Dauphinee

• BC Cancer Research Centre, Vancouver, Canada

  Aly Karsan

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