Overview
Covers cardiocirculatory shock in a comprehensive yet easy-to-read format
Broadens understanding of Methylene Blue
Shares the knowledge of a highly experienced authority in the field of Cardiovascular Surgery
Collates worldwide experimental and clinical cases
Appeals to a wide range of health professionals
Sets the direction for future research
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Table of contents (18 chapters)
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General Conceptual Aspects
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Particularities of Endothelial Dysfunction in Different Types of Shock
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Methylene Blue
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Endothelial Dysfunction in Specific Situations
Keywords
About this book
This unique work presents one of the most significant organ failure condition – cardiocirculatory shock – and the prominent role of Methylene Blue (MB). Through their extensive experience, the authors’ consider that the lifesaving feature of MB is still underestimated. For this reason they outline key concepts of MB, mentioning essential experimental data, yet focusing mainly on its application in the care of critically ill patients.
In an easy-to-read format, the 18 chapters were organized in a didactically structured order, distributed in four parts. The first part introduces the general conceptual aspects and physiology of the endothelium. The second part presents the particularities of endothelial dysfunction in different types of shock. Methylene blue is discussed in detail in the third part. In the fourth part, particular situations of endothelial dysfunction, such as heart surgery and organ transplantation, are described. Additionally, the two complementary subjects of acid-base balance and the therapeutic use of inhaled nitric oxide are mentioned.
Finally, looking for therapeutic alternatives for what we classify as "vasoplegic endothelial dysfunction", MB remains promising as an adjuvant to sympathomimetic amines. The combination of three recently proposed concepts may be useful in obtaining better results against the high mortality rates in critically ill patients. These three concepts are "wide-spectrum vasopressors", vasopressor economy strategies, and microcirculation protection against the harmful effects of using high concentrations of amines.
This book´s translational approach will appeal to a variety of readers within the health specialties of medicine, biomedicine, physiotherapy, nursing, odontology, and basic science.
Authors and Affiliations
About the authors
Paulo Roberto Barbosa Evora
Graduated in Medicine from the Ribeirão Preto School of Medicine, University of São Paulo – USP (1972). At the same institution, he completed residencies in General Surgery (1973) and Thoracic and Cardiovascular Surgery (1974), and a PhD also in General Surgery (1980). Dr. Evora was Coordinator of the Endothelial Function Laboratory of the Experimental Surgery Division and Collaborating Researcher in Cardiovascular Surgical Research at the Mayo Clinic, Rochester, MN, USA. Associate Professor (1994) and Full Professor (2004) of the Department of Surgery, Orthopedics and Traumatology at the Ribeirão Preto School of Medicine, USP (1993), clinical director of the Intensive Care Center at the Hospital das Clínicas of the Ribeirão Preto School of Medicine - USP, Coordinator of the postgraduate program (2004-2006), Vice-Head of the Department (2004-2006), Head of the Department (2007-2008), member of the Research Committee of the Ribeirão Preto School of Medicine, and member of the Bioterio Central Commission of the USP Ribeirão Preto Campus, and Editor-in-chief of the Brazilian Journal of Cardiovascular Surgery.
Andrea Carla Celotto
Graduated in Biomedicine from the University of Franca (2002), obtained a Master’s degree in Pharmaceutical Sciences from the Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP (2005), and completed a PhD in Sciences at the Ribeirão Preto School of Medicine - USP (2009). She also completed a PhD internship at the Vascular Biology Laboratory at Mayo Clinic, Rochester, MN, USA and a post-doctorate at the Endothelial Function Laboratory of the Department of Surgery and Anatomy at Ribeirão Preto School of Medicine - USP (2013). Former professor at the University of Franca, Dr. Celotto is currently a professor of the Faculty of Health Sciences of Barretos Dr. Paulo Prata and an Associate Researcher of the Department of Surgery and Anatomy, Ribeirão Preto School of Medicine – USP. She has extensive experience in Physiology, Pathophysiology and Pharmacology.
Agnes Afrodite Sumarelli Albuquerque
Bachelor’s degree in Biological Sciences from Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal campus (2005) and specialization in Genetic Engineering and Molecular Biology (2009). She obtained a Master’s degree (2012) and completed a PhD (2018) in Morphology and Experimental Medicine Surgical Clinic. Laboratory Technician at the Department of Surgery and Anatomy of the Ribeirão Preto Medical School of the University of São Paulo.
Patricia Martinez Évora
Graduated in Veterinary Medicine from the Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal campus (2008). Completed internships at Ohio State University, Columbus, OH, USA, in the fields of equine medical clinic and Molecular Biology (2008). She obtained a Master's degree in Veterinary Medicine (2012) and completed a PhD in Animal Pathology from the Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal campus (2017). Dr. Évora is currently a postdoctoral fellow in Immunoparasitology at the Ribeirão Preto School of Medicine - USP.
Bibliographic Information
Book Title: Vasoplegic Endothelial Dysfunction
Book Subtitle: Circulatory Shock and Methylene Blue
Authors: Paulo Roberto Barbosa Evora, Andrea Carla Celotto, Agnes Afrodite Sumarelli Albuquerque, Patricia Martinez Évora
DOI: https://doi.org/10.1007/978-3-030-74096-2
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-74095-5Published: 01 June 2021
Softcover ISBN: 978-3-030-74098-6Published: 02 June 2022
eBook ISBN: 978-3-030-74096-2Published: 31 May 2021
Edition Number: 1
Number of Pages: XXIII, 144
Number of Illustrations: 11 b/w illustrations, 3 illustrations in colour
Additional Information: Original Portuguese edition published by Editora Atheneu Ltda., São Paulo, Brazil, 2011
Topics: Internal Medicine, Cardiology, Biomedicine, general, Nursing, Physiotherapy