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Reactive Oxygen Species

Network Pharmacology and Therapeutic Applications

  • Book
  • © 2021

Overview

Editors:
  1. Harald H. H. W. Schmidt

    1. Department of Pharmacology and Personalised Medicine, Maastricht University, Maastricht, The Netherlands

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  2. Pietro Ghezzi

    1. Brighton and Sussex Medical School, Brighton, UK

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  3. Antonio Cuadrado

    1. Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain

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  • This book is a game changer for the field and many clinical areas such as cardiology and neurology
  • Suggests a new approach to reactive oxygen species (ROS) and opens a new chapter in redox medicine
  • Leading book and reference for many years to come

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 264)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
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  2. ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine

    1. Front Matter

      Pages 1-1
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    2. Demystifying Oxidative Stress

      • Pietro Ghezzi, Arshag D. Mooradian
      Pages 3-26

    3. Oxidants in Physiological Processes

      • Ulla G. Knaus
      Pages 27-47

    4. Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies

      • Cristian Nogales, Alexander G. B. Grønning, Sepideh Sadegh, Jan Baumbach, Harald H. H. W. Schmidt
      Pages 49-68

  3. Targeting Antioxidant Responses

    1. Front Matter

      Pages 69-69
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    2. Development of Telintra as an Inhibitor of Glutathione S-Transferase P

      • Jie Zhang, Zhi-Wei Ye, Yvonne Janssen-Heininger, Danyelle M. Townsend, Kenneth D. Tew
      Pages 71-91

    3. Perspectives on the Clinical Development of NRF2-Targeting Drugs

      • Diego Lastra, Raquel Fernández-Ginés, Gina Manda, Antonio Cuadrado
      Pages 93-141

  4. Inhibiting ROS Formation and Toxification

    1. Front Matter

      Pages 143-143
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    2. NOX Inhibitors: From Bench to Naxibs to Bedside

      • Mahmoud H. Elbatreek, Hermann Mucke, Harald H. H. W. Schmidt
      Pages 145-168

    3. Nitric Oxide Synthase Inhibitors into the Clinic at Last

      • Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Thomas Fuchß, Ulrich Grädler, Harald H. H. W. Schmidt, Ajay M. Shah et al.
      Pages 169-204

    4. Xanthine Oxidoreductase Inhibitors

      • Keeran Vickneson, Jacob George
      Pages 205-228

    5. Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches

      • Pablo Duarte, Antonio Cuadrado, Rafael León
      Pages 229-259

    6. Inhibition of Myeloperoxidase

      • Jala Soubhye, Paul G. Furtmüller, Francois Dufrasne, Christian Obinger
      Pages 261-285

  5. Stimulating/Substituting ROS

    1. Front Matter

      Pages 287-287
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    2. Effects of Mammalian Thioredoxin Reductase Inhibitors

      • Elias S. J. Arnér
      Pages 289-309

    3. Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation

      • Barbara K. Kemp-Harper, Anida Velagic, Nazareno Paolocci, John D. Horowitz, Rebecca H. Ritchie
      Pages 311-337

    4. Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers

      • Keith M. Channon
      Pages 339-352

  6. Repairing ROS Damage

    1. Front Matter

      Pages 353-353
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    2. Soluble Guanylate Cyclase Stimulators and Activators

      • Peter Sandner, Daniel P. Zimmer, G. Todd Milne, Markus Follmann, Adrian Hobbs, Johannes-Peter Stasch
      Pages 355-394Open Access
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Keywords

About this book

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leadingreference for ROSopathies and their treatment by network pharmacology.  

Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.  


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Editors and Affiliations

  • Department of Pharmacology and Personalised Medicine, Maastricht University, Maastricht, The Netherlands

    Harald H. H. W. Schmidt

  • Brighton and Sussex Medical School, Brighton, UK

    Pietro Ghezzi

  • Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain

    Antonio Cuadrado

About the editors

  

Bibliographic Information

  • Book Title: Reactive Oxygen Species

  • Book Subtitle: Network Pharmacology and Therapeutic Applications

  • Editors: Harald H. H. W. Schmidt, Pietro Ghezzi, Antonio Cuadrado

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-030-68510-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-68509-6Published: 24 February 2021

  • Softcover ISBN: 978-3-030-68512-6Published: 24 February 2022

  • eBook ISBN: 978-3-030-68510-2Published: 23 February 2021

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VIII, 425

  • Number of Illustrations: 70 illustrations in colour

  • Topics: Pharmacology/Toxicology, Cardiology, Neurosciences, Medical Biochemistry

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