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Brain Hypoxia and Ischemia

  • Book
  • © 2009

Overview

Editors:
  1. Gabriel G. Haddad

    1. University of California, San Diego
      Rady Children's Hospital, San Diego

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    You can also search for this editor in PubMed   Google Scholar

  2. Shan Ping Yu

    1. Emory University, Atlanta

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Most up-to-date volume to focus on the mechanisms of cell injury and cell survival in the brain, with special emphasis on development and early life, in relation to hypoxia and ischemia in the brain.
  • Comments on the developmental stages of the brain is the major societal and economic burden of the affliction when it occurs in early life.

Part of the book series: Contemporary Clinical Neuroscience (CCNE)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Ion Channels, Transporters and Excitotoxicity

    1. Regulation of Vulnerability to NMDA Excitotoxicity During Postnatal Maturation

      • Jeremy D. Marks
      Pages 3-24

    2. Acidosis, Acid-Sensing Ion Channels, and Glutamate Receptor-Independent Neuronal Injury

      • Z. Xiong
      Pages 25-41

    3. Brain Ischemia and Neuronal Excitability

      • Ping Deng, Zao C. Xu
      Pages 43-52

    4. Critical Roles of the Na+/K+-ATPase in Apoptosis and CNS Diseases

      • Adrian Sproul, Xin Zhou, Shan Ping Yu
      Pages 53-78

    5. Emerging Role of Water Channels in Regulating Cellular Volume During Oxygen Deprivation and Cell Death

      • Thomas James Younts, Jr. Francis “Monty” Hughes
      Pages 79-96

    6. A Zinc—Potassium Continuum in Neuronal Apoptosis

      • Patrick Redman, Megan Knoch, Elias Aizenman
      Pages 97-115

    7. Mitochondrial Ion Channels in Ischemic Brain

      • Elizabeth A. Jonas
      Pages 117-150

  3. Reactive Oxygen Species, and Gene Expression to Behavior

    1. Perinatal Panencephalopathy in Premature Infants: Is It Due to Hypoxia-Ischemia?

      • Hannah C. Kinney, Joseph J. Volpe
      Pages 153-185

    2. Effects of Intermittent Hypoxia on Neurological Function

      • David Gozal
      Pages 187-212

    3. Brainstem Sensitivity to Hypoxia and Ischemia

      • Joseph C. LaManna, Paola Pichiule, Kui Xu, Juan Carlos Chávez
      Pages 213-223

    4. Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia

      • Zezong Gu, Jiankun Cui, Stuart A. Lipton
      Pages 225-238

    5. Oxidative Stress in Hypoxic-Ischemic Brain Injury

      • Laura L. Dugan, M. Margarita Behrens, Sameh S. Ali
      Pages 239-254

    6. Postnatal Hypoxia and the Developing Brain: Cellular and Molecular Mechanisms of Injury

      • Robert M. Douglas
      Pages 255-276

    7. Hypoxia-Inducible Factor 1

      • Gregg L. Semenza
      Pages 277-288

    8. Transcriptional Response to Hypoxia in Developing Brain

      • Dan Zhou
      Pages 289-306

    9. Acute Stroke Therapy: Highlighting the Ischemic Penumbra

      • Hang Yao
      Pages 307-322

    10. Genes and Survival to Low O2 Environment: Potential Insights from Drosophila

      • Gabriel G. Haddad
      Pages 323-333

  4. Back Matter

    Pages 335-343
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Keywords

About this book

Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development.

This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.

Editors and Affiliations

  • University of California, San Diego

    Gabriel G. Haddad

  • Rady Children's Hospital, San Diego

    Gabriel G. Haddad

  • Emory University, Atlanta

    Shan Ping Yu

Bibliographic Information

  • Book Title: Brain Hypoxia and Ischemia

  • Editors: Gabriel G. Haddad, Shan Ping Yu

  • Series Title: Contemporary Clinical Neuroscience

  • DOI: https://doi.org/10.1007/978-1-60327-579-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Humana Press 2009

  • Hardcover ISBN: 978-1-60327-578-1Published: 12 December 2008

  • Softcover ISBN: 978-1-61737-914-7Published: 09 December 2010

  • eBook ISBN: 978-1-60327-579-8Published: 06 January 2009

  • Series ISSN: 2627-535X

  • Series E-ISSN: 2627-5341

  • Edition Number: 1

  • Number of Pages: XII, 268

  • Number of Illustrations: 21 b/w illustrations, 26 illustrations in colour

  • Topics: Neurosciences, Human Physiology, Neurology, Neurobiology

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