From Melanocytes to Melanoma

1. Front Matter

   Pages i-xvii

   PDF

2. Melanocyte Development and Function

   1. Front Matter

      Pages 1-1

      PDF

   2. The Origin and Development of Neural Crest-Derived Melanocytes

      • Debra L. Silver, William J. Pavan

      Pages 3-26

   3. MITF

      • Heinz Arnheiter, Ling Hou, Minh-Thanh T. Nguyen, Keren Bismuth, Tamas Csermely, Hideki Murakami et al.

      Pages 27-49

   4. MITF

      • Erez Feige, Laura L. Poling, David E. Fisher

      Pages 51-69

   5. Melanocytes and the Transcription Factor Sox10

      • Michael Wegner

      Pages 71-80

   6. Human Cutaneous Pigmentation

      • Zalfa A. Abdel-Malek, Ana Luisa Kadekaro

      Pages 81-100

   7. Melanocyte Distribution and Function in Human Skin

      • Yuji Yamaguchi, Vincent J. Hearing

      Pages 101-115

3. Melanocyte Transformation and Progression to Melanoma

   1. Front Matter

      Pages 117-117

      PDF

   2. Altered Signal Transduction in Melanoma

      • Pablo López Bergam, Anindita Bhoumik, Ze’ev Ronai

      Pages 119-147

   3. BRN2 in Melanocytic Cell Development, Differentiation, and Transformation

      • Anthony L. Cook, Glen M. Boyle, J. Helen Leonard, Peter G. Parsons, Richard A. Sturm

      Pages 149-167

   4. The Dynamic Roles of Cell-Surface Receptors in Melanoma Development

      • Dong Fang, Meenhard Herlyn

      Pages 169-181

   5. Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation

      • Dorothy C. Bennett

      Pages 183-196

   6. Genetic Progression From Melanocyte to Malignant Melanoma

      • Boris C. Bastian

      Pages 197-209

   7. The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma

      • Dahu Chen, Qiushi Lin, I. Saira Mian, Jon Reed, Estela E. Medrano

      Pages 211-222

   8. RB/E2F Regulation and Dual Activity in the Melanocytic System

      • Ruth Halaban

      Pages 223-245

   9. Melanoma Development and Pigment Cell Transformation

      • Claudia Wellbrock

      Pages 247-263

   10. The Biology and Genetics of Melanoma

       • Norman E. Sharpless, Lynda Chin

       Pages 265-290

   11. The Biology of Xeroderma Pigmentosum

       • James E. Cleaver

       Pages 291-310

   12. Divergent Pathways to Cutaneous Melanoma

       • David C. Whiteman, Adèle C. Green

       Pages 311-327

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

• DNA
• apoptosis
• cancer
• cell
• genetics
• imaging
• immunotherapy
• melanoma
• metastasis
• skin
• therapy
• tumor
• tumor progression

From the reviews:

"...this compendium of current thinking is recommended reading for anyone with an interest in pigmentation and cancer and a valuable resource for any library." -Melanoma Research

"This book, the first of its kind on melanoma, details the current state of our knowledge … . should be viewed as an important resource for understanding the broad field of melanocyte and melanoma biology. Newcomers to the field … will find this book extremely useful. … This book captures the tremendous progress made in the field … . It is a valuable resource for biologists and basic scientists … as well as for pathologists; dermatologists, surgeons, and medical oncologists … ." (Lynn M. Schuchter, The New England Journal of Medicine, March, 2007)

"...captures the tremendous progress made in the field...will help to propel the field to new successes...a valuable resource for biologists and basic scientists interested in the biology of pigment cells as well as for pathologists, dermatologists, surgeons, and medical oncologists interested in the diagnosis and treatment of melanoma." -New England Journal of Medicine

"The editors have compiled a highly prestigious group of authors, who are leaders in the field of melanocyte and melanoma research, to present a very comprehensive exposition of the current knowledge of melanocyte biology and melanoma. … As a clinical researcher, I found … it fascinating, yielding a tremendous appreciation for the meticulous and extensive work that has been done to date, some of which has and more of which will very likely provide leads to clinical interventions." (Janice P. Dutcher, Medical Oncology, Vol. 23 (3), 2006)

"An extremely detailed book on each of the various pathways, growth factors, and oncogenes affecting the melanocyte. This is a comprehensive review and … physicians such as dermatologists, pathologists, and oncologists will find it helpful. It is very thorough in itspresentation of cellular events … . This book will serve primarily as a reference for basic scientists and biologists. Physician scientists will also use the book. Clinicians may find the book highly detailed, with more information then they require." (Mary C. Martini, Doody’s Review Service, July, 2006)

• Laboratory of Cell Biology National Cancer Institute, National Institutes of Health, Bethesda

  Vincent J. Hearing

• Department of Surgery, University of California, San Francisco

  Stanley P. L. Leong

• School of Medicine, San Francisco

  Stanley P. L. Leong

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