Bioimaging in Neurodegeneration

1. Front Matter

   Pages i-xvi

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2. Parkinson’s Disease

   1. Front Matter

      Pages 1-1

      PDF

   2. Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Parkinson’s Disease

      • W. R. Wayne Martin

      Pages 3-12

   3. Positron Emission Tomography and Single-Photon Emission Tomography in the Diagnosis of Parkinson’s Disease

      • Paul D. Acton

      Pages 13-24

   4. Positron Emission Tomography in Parkinson’s Disease

      • André R. Troiano, A. Jon Stoessl

      Pages 25-35

   5. [123I]-Altropane SPECT

      • Hubert H. Fernandez, Paula D. Ravin, Dylan P. Wint

      Pages 37-44

   6. Positron Emission Tomography and Embryonic Dopamine Cell Transplantation in Parkinson’s Disease

      • Yilong Ma, Vijay Dhawan, Curt Freed, Stanley Fahn, David Eidelberg

      Pages 45-57

3. Alzheimer’s Disease

   1. Front Matter

      Pages 59-59

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   2. Neurotoxicity of the Alzheimer’s β-Amyloid Peptide

      • David R. Howlett

      Pages 61-74

   3. Functional Imaging and Psychopathological Consequences of Inflammation in Alzheimer’s Dementia

      • Jan Versijpt, Rudi A. Dierckx, Jakob Korf

      Pages 75-83

   4. Neurotoxic Oxidative Metabolite of Serotonin

      • Ladislav Volicer, Monika Z. Wrona, Wayne Matson, Glenn Dryhurst

      Pages 85-93

   5. Predicting Progression of Alzheimer’s Disease With Magnetic Resonance

      • Kejal Kantarci, Clifford R. Jack Jr.

      Pages 95-105

   6. Stages of Brain Functional Failure in Alzheimer’s Disease

      • Stanley I. Rapoport

      Pages 107-119

4. Epilepsy

   1. Front Matter

      Pages 121-121

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   2. Neocortical Epilepsy

      • Jun Natsume, Andrea Bernasconi, Mirko Diksic

      Pages 123-129

   3. Pediatric Cortical Dysplasia

      • Bharathi Dasan Jagadeesan, Csaba Juhász, Diane C. Chugani, Harry T. Chugani

      Pages 131-140

   4. Bioimaging L-Tryptophan in Human Hippocampus and Neocortex

      • Steven V. Pacia, Patricia A. Broderick

      Pages 141-147

   5. In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsy

      • Sonya Bahar, Minah Suh, Ashesh Mehta, Theodore H. Schwartz

      Pages 149-175

   6. Intraoperative Magnetic Resonance Imaging in the Surgical Treatment of Epilepsy

      • Theodore H. Schwartz

      Pages 177-192

   7. Periodic Epileptiform Discharges Associated With Increased Cerebral Blood Flow

      • Imran I. Ali, Noor A. Pirzada

      Pages 193-197

Bioimaging is in the forefront of medicine for the diagnosis and helps to predict the progression of AD via mild cognitive treatment of neurodegenerative disease. Conventional magnetic impairment (MCI) studies. resonance imaging (MRI) uses interactive external magnetic fields Novel neuroimaging technologies, such as neuromolecular and resonant frequencies of protons from water molecules. imaging (NMI) with a series of newly developed BRODERICK ® However, newer sequences, such as magnetization-prepared rapid PROBE sensors, directly image neurotransmitters, precursors, acquisition gradient echo (MPRAGE), are able to seek higher and metabolites in vivo, in real time and within seconds, at separate levels of anatomic resolution by allowing more rapid temporal and selective waveform potentials. NMI, which uses an imaging. Magnetic resonance spectroscopy (MRS) images electrochemical basis for detection, enables the differentiation of metabolic changes, enabling underlying pathophysiologic neurodegenerative diseases in patients who present with mesial dysfunction in neurodegeneration to be deciphered. Neuro- versus neocortical temporal lobe epilepsy. In fact, NMI has some 1 chemicals visible with proton H MRS include N-acetyl aspartate remarkable similarities to MRI insofar as there is technological (NAA), creatine/phosphocreatine (Cr), and choline (Cho); NAA dependence on electron and proton transfer, respectively, and is considered to act as an in vivo marker for neuronal loss and/or further dependence is seen in both NMI and MRI on tissue neuronal dysfunction. By extending imaging to the study of composition such as lipids.

• Alzheimer
• Parkinson
• anatomy
• cortex
• neurons

"The editors have succeeded in creating a bridge between the molecular biology of important neurodegenrative disorders and advances in brain imaging." - Journal of Neurosurgery

"...highly recommended to readers who require a solid review and reference text on the state of the art in bioimaging in neurodegenrative diseases." - Annals of Neurology

• Department of Physiology and Pharmacology, City University of New York Medical School, New York

  Patricia A. Broderick

• Department of Neurology, New York University School of Medicine, New York

  Patricia A. Broderick, Edwin H. Kolodny

• NYU Comprehensive Epilepsy Center, New York

  Patricia A. Broderick

• Department of Chemistry and Physical Sciences, Pace University, Pleasantville

  David N. Rahni

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