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Pluripotency in Domestic Animal Cells

  • Book
  • © 2013

Overview

Authors:
  1. Tiziana A.L. Brevini

    1. Laboratory of Biomedical Embryology Anatomy and Histology, Università degli Studi di Milano Unistem, Milan, Italy

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  2. Fulvio Gandolfi

    1. Laboratory of Biomedical Embryology Anatomy and Histology, Università degli Studi di Milano Unistem, Milan, Italy

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  • Focuses on the specific mechanisms that control pluripotency and cell commitment in domestic animal species
  • Addresses the need large animal models for regenerative medicine
  • Describes early embryo development by analyzing the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species

Part of the book series: SpringerBriefs in Stem Cells (BRIEFSSTEM)

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Table of contents (3 chapters)

  1. Front Matter

    Pages i-vii
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  2. Early Embryo Development in Large Animals

    • Tiziana A. L. Brevini, Fulvio Gandolfi
    Pages 1-19

  3. Pluripotency in Domestic Animal Embryos

    • Tiziana A. L. Brevini, Fulvio Gandolfi
    Pages 21-27

  4. Use of Large Animal Models for Regenerative Medicine

    • Tiziana A. L. Brevini, Fulvio Gandolfi
    Pages 29-42

  5. Back Matter

    Pages 43-46
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Keywords

About this book

This addition to the Springer Brief in Stem Cells series focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating rapidly-increasing interest due to the great potential for domestic animal species to be used as intermediate biomedical models, between the mouse and the human. The Brief addresses why we need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.

Authors and Affiliations

  • Laboratory of Biomedical Embryology Anatomy and Histology, Università degli Studi di Milano Unistem, Milan, Italy

    Tiziana A.L. Brevini, Fulvio Gandolfi

About the authors

Dr. Tiziana Brevini is a professor in the Department of Animal Science, Laboratory of Biomedical Embryology, at the University of Milan. She is a reviewer for both the European Science Foundation and the United States National Science Foundation. She has authored over 140 publications on cell proliferation and differentiation, gametogenesis, embryo development and stem cell biology.

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