Oocyte Biology in Fertility Preservation

1. Front Matter

   Pages i-x

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2. The Importance of Oocyte Biology for the Future of Fertility Preservation

   • S. Samuel Kim

   Pages 1-5

3. The Control of Oocyte Survival by Intrinsic and Extrinsic Factors

   • Meltem Kurus, Cengiz Karakaya, Mete Hakan Karalok, Grace To, Joshua Johnson

   Pages 7-18

4. Effects of Fertility Preservation on Oocyte Genomic Integrity

   • David F. Albertini, Rachel Olsen

   Pages 19-27

5. In Vitro Activation of Dormant Follicles for Fertility Preservation

   • Deepak Adhikari

   Pages 29-42

6. Primate Follicular Development and Oocyte Maturation In Vitro

   • Jing Xu, Min Xu, Marcelo P. Bernuci, Thomas E. Fisher, Lonnie D. Shea, Teresa K. Woodruff et al.

   Pages 43-67

7. Vitrification of Oocytes: From Basic Science to Clinical Application

   • Amir Arav, Yehudit Natan

   Pages 69-83

8. Memoir of Fertility Preservation

   • Roger G. Gosden

   Pages 85-94

9. Back Matter

   Pages 95-97

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​Fertility preservation has become one of the most important and fast growing fields of reproductive medicine.  Although there are several strategies for fertility preservation in female, most of them are still considered experimental.  It is important to perfect the existing technologies, but also developing new strategies should be actively sought.  The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles.  One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms.  To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level.  Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation.  The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.​ 

• Epigenetics
• Fertility Preservation
• Follicle Development
• Oocytes
• Ovarian Biology
• Reproductive Techonologies

• University of Kansas Medical Center, Kansas City, USA

  S. Samuel Kim

S. Samuel Kim is on the editorial board of the Journal of Assisted Reproduction and Genetics, an official publication of the American Society for Reproductive Medicine. He works closely with the journal's Editor-in-Chief, David Albertini, at the University of Kansas Medical Center, with which they are both affiliated.

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