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Molecular Genetic Pathology

  • Reference work
  • © 2013

Overview

Editors:
  1. Liang Cheng

    1. School of Medicine, Dept. Pathology, Indiana University, Indianapolis, USA

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  2. David Y. Zhang

    1. Dept. Pathology, Mount Sinai School of Medicine, New York, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. John N. Eble

    1. School of Medicine, Department of Pathology and, Indiana University, Indianapolis, USA

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  • Extensively revised and expanded to cover all aspects of molecular genetic pathology

  • Written by internationally recognized authorities

  • Most commonly used techniques and their clinical applications

  • Concise outline format for quick reference

  • Up-to-date references, principles and explanations

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Table of contents (46 entries)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  2. Basic Principles in Molecular Genetic Pathology

    1. Front Matter

      Pages 1-1
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    2. Clinical Molecular Biology: Principles

      • Shaobo Zhang, Darrell D. Davidson, Liang Cheng
      Pages 3-41

    3. Clinical Cytogenetics: Principles

      • Stuart Schwartz
      Pages 43-76

    4. Conceptual Evolution in Cancer Biology

      • Shaobo Zhang, Darrell D. Davidson, Rodolfo Montironi, Antonio Lopez-Beltran, Gregory T. MacLennan, Liang Cheng
      Pages 77-109

    5. Genetic Inheritance and Population Genetics

      • Tatiana Foroud, Daniel L. Koller
      Pages 111-127

    6. Clonality Analysis and Tumor of Unknown Primary: Applications in Modern Oncology and Surgical Pathology

      • Liang Cheng, Shaobo Zhang, Federico A. Monzon, Timothy D. Jones, John N. Eble
      Pages 129-180

    7. Modern Immunohistochemistry in Targeted Therapy

      • Allen M. Gown
      Pages 181-196

    8. Systems Pathology

      • José Costa, Michael J. Donovan
      Pages 197-207

  3. Methodology in Molecular Genetic Pathology

    1. Front Matter

      Pages 209-209
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    2. Diagnostic Methodology and Technology in Molecular Genetic Pathology

      • Josephine Wu, Fei Ye, Miao Cui, Robert Shibata, Ruliang Xu, Liang Cheng et al.
      Pages 211-300

    3. Clinical Flow Cytometry in Molecular Genetic Pathology

      • Magdalena Czader
      Pages 301-334

    4. Clinical Genomics in Oncology

      • Hugo M. Horlings, Thalia A. Farazi, Marc J. van de Vijver
      Pages 335-368

    5. Clinical Proteomics in Molecular Genetic Pathology

      • David H. Geho, Virgina Espina, Lance A. Liotta, Emanuel F. Petricoin, Julia D. Wulfkuhle
      Pages 369-381

    6. Nanotechnology in Molecular Diagnostics

      • Andrew N. Young, Brad A. Kairdolf
      Pages 383-398

    7. Gene Therapy: Vector Technology and Clinical Applications

      • Sunyong Tang, Kenneth Cornetta
      Pages 399-412

    8. Instrumentation for Molecular Testing

      • Jordan Laser, Miao Cui, Bruce E. Petersen, Fei Ye, David Y. Zhang
      Pages 413-454

    9. Tissue Microarrays and Biomarker Validation in Molecular Diagnostics

      • Martina Storz, Holger Moch
      Pages 455-463

    10. Laser Capture Microdissection in Molecular Diagnostics

      • Liang Cheng, Shaobo Zhang, Darrell D. Davidson, Matthew Kuhar, Mingsheng Wang, Sean R. Williamson et al.
      Pages 465-482

    11. Human Tissue Biorepository

      • William E. Grizzle, Katherine C. Sexton, Walter C. Bell
      Pages 483-497
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Keywords

About this book

Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists.  Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.

Reviews

From the reviews of the second edition:

“This two-volume set covers many laboratory and clinical aspects of molecular diagnostics. … The purpose is to provide a quick reference for molecular diagnostic testing in the practice of pathology. … It is intended for ‘pathologists, oncologists, geneticists, primary care physicians and other medical professionals with an interest in this specialty,’ including residents and fellows. Clinical laboratory scientists (students or in training) also might find it useful.” (Valerie L. Ng, Doody’s Book Reviews, June, 2013)

Editors and Affiliations

  • School of Medicine, Dept. Pathology, Indiana University, Indianapolis, USA

    Liang Cheng

  • Dept. Pathology, Mount Sinai School of Medicine, New York, USA

    David Y. Zhang

  • School of Medicine, Department of Pathology and, Indiana University, Indianapolis, USA

    John N. Eble

About the editors

Liang Cheng, M.D.
Indiana University School of Medicine, Indianapolis, IN, USA

David Zhang, M.D.
Mount Sinai School of Medicine, New York, NY, USA

John N. Eble, M.D.
Indiana University School of Medicine, Indianapolis, IN, USA

Bibliographic Information

  • Book Title: Molecular Genetic Pathology

  • Editors: Liang Cheng, David Y. Zhang, John N. Eble

  • DOI: https://doi.org/10.1007/978-1-4614-4800-6

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Reference Module Medicine

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-4799-3Published: 05 March 2013

  • eBook ISBN: 978-1-4614-4800-6Published: 14 March 2013

  • Edition Number: 2

  • Number of Pages: XXI, 1136

  • Number of Illustrations: 95 b/w illustrations, 347 illustrations in colour

  • Topics: Pathology, Oncology, Hematology, Laboratory Medicine

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