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Kainate Receptors

Novel Signaling Insights

  • Examines the functional actions of the kainate-type glutamate receptors (KARs)
  • Provides new insights into how KARs inhibit the slow after-hyperpolarisation current
  • Gives insights into KAR interaction with intracellular binding partners

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 717)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xx
  2. Metabotropic Actions of Kainate Receptors in the Control of GABA Release

    • Talvinder S. Sihra, Antonio Rodríguez-Moreno
    Pages 1-10
  3. Kainate Receptor Modulation by Sodium and Chloride

    • Andrew J. R. Plested
    Pages 93-113
  4. BTB-Kelch Proteins and Ubiquitination of Kainate Receptors

    • John Marshall, Leslie A. C. Blair, Jeffrey D. Singer
    Pages 115-125
  5. Concluding Remarks

    • Antonio Rodriguez-Moreno, Talvinder S. Sihra
    Pages 127-127
  6. Back Matter

    Pages 129-131

About this book

This volume critically examines the functional actions of the kainate‑type glutamate receptors (KARs). Following on from the larger body of work on the NMDA‑ and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions.

Editors and Affiliations

  • Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain

    Antonio Rodríguez-Moreno

  • Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

    Talvinder S. Sihra

About the editors

ANTO NIO RODRIGUEZ‑MORENO is Associate Professor and Head of the Cellular Neuroscience and Plasticity Laboratory at the University Pablo de Olavide, in Seville, Spain. His main research interests include the study of the mechanisms of synaptic plasticity in cortex and hippocampus and the physiology of glutamate receptors of the NMDA and kainate type. He is a member of the Federation of European Neuroscience Societies (FENS) and the Society for Neuroscience (SFN). Following a degree in Biological Sciences at the University of Seville, Dr. Rodriguez‑Moreno received his PhD degree in Neurobiology and Molecular Biology from Cajal Institute and the University Automous of Madrid in Madrid, Spain. During a first postdoc at the University Pablo de Olavide, in Seville (Spain) he studied the mechanisms of learning and memory in awake animals. This was followed by a postdoctoral stay at University College London (UK) where he investigated the actions of kainate receptors using synaptosomes and brain slices. During a third postdoc at University of Oxford, he started to study the mechanisms of brain plasticity processes.

 

 

TAL VINDER S. SIHRA is a Reader in Cellular and Molecular Neuroscience, and Teaching Lead in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL) UK. His main research interests are in the elucidation and characterisation of presynaptic receptors and downstream signaling pathways involved in the modulation of neurotransmitter release. Pursuant to an undergraduate degree in Biochemistry and Physiology from the University of Sheffield, UK, he completed his PhD (Biochemistry) in 1985 at the University of Dundee, Scotland, where he initiated his studies looking at the mechanisms underlying amino acid neurotransmitter release. He extended these studies at the Rockefeller University,New York, USA, in the laboratory of Professor Paul Greengard, Nobel Laureate in Medicine (2000), looking at the role of protein phosphorylation in presynaptic function and plasticity. In 1993, he obtained a faculty position at the University of London (Royal Free Hospital School of Medicine), and continued thereafter at UCL. Dr. Sihra is a member of the Biochemical Society (UK) and currently on the Signalling theme panel for the Society. He is a member of the Society of Neuroscience and former editor of the British Journal of Pharmacology.

TAL VINDER S. SIHRA is a Reader in Cellular and Molecular Neuroscience, and Teaching Lead in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL) UK. His main research interests are in the elucidation and characterisation of presynaptic receptors and downstream signaling pathways involved in the modulation of neurotransmitter release. Pursuant to an undergraduate degree in Biochemistry and Physiology from the University of Sheffield, UK, he completed his PhD (Biochemistry) in 1985 at the University of Dundee, Scotland, where he initiated his studies looking at the mechanisms underlying amino acid neurotransmitter release. He extended these studies at the Rockefeller University, New York, USA, in the laboratory of Professor Paul Greengard, Nobel Laureate in Medicine (2000), looking at the role of protein phosphorylation in presynaptic function and plasticity. In 1993, he obtained a faculty position at the University of London (Royal Free Hospital School of Medicine), and continued thereafter at UCL. Dr. Sihra is a member of the Biochemical Society (UK) and currently on the Signalling theme panel for the Society. He is a member of the Society of Neuroscience and former editor of the British Journal of Pharmacology.

TAL VINDER S. SIHRA is a Reader in Cellular and Molecular Neuroscience, and Teaching Lead in the Department ofNeuroscience, Physiology and Pharmacology at University College London (UCL) UK. His main research interests are in the elucidation and characterisation of presynaptic receptors and downstream signaling pathways involved in the modulation of neurotransmitter release. Pursuant to an undergraduate degree in Biochemistry and Physiology from the University of Sheffield, UK, he completed his PhD (Biochemistry) in 1985 at the University of Dundee, Scotland, where he initiated his studies looking at the mechanisms underlying amino acid neurotransmitter release. He extended these studies at the Rockefeller University, New York, USA, in the laboratory of Professor Paul Greengard, Nobel Laureate in Medicine (2000), looking at the role of protein phosphorylation in presynaptic function and plasticity. In 1993, he obtained a faculty position at the University of London (Royal Free Hospital School of Medicine), and continued thereafter at UCL. Dr. Sihra is a member of the Biochemical Society (UK) and currently on the Signalling theme panel for the Society. He is a member of the Society of Neuroscience and former editor of the British Journal of Pharmacology.

Bibliographic Information

  • Book Title: Kainate Receptors

  • Book Subtitle: Novel Signaling Insights

  • Editors: Antonio Rodríguez-Moreno, Talvinder S. Sihra

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4419-9557-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2011

  • Hardcover ISBN: 978-1-4419-9556-8Published: 25 April 2011

  • eBook ISBN: 978-1-4419-9557-5Published: 28 June 2011

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XX, 131

  • Topics: Biomedicine general, Molecular Medicine

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access