Overview
- outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Cancer Research (CUCR)
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Table of contents (11 chapters)
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Front Matter
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Starting the Cell Division Cycle
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Front Matter
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Proliferation Under Duress
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Front Matter
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Applications in Preventing and Treating Cancer
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Front Matter
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Back Matter
Keywords
About this book
Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
Editors and Affiliations
Bibliographic Information
Book Title: Cell Cycle Deregulation in Cancer
Editors: Greg H. Enders
Series Title: Current Cancer Research
DOI: https://doi.org/10.1007/978-1-4419-1770-6
Publisher: Springer New York, NY
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media, LLC 2010
Hardcover ISBN: 978-1-4419-1769-0Published: 22 March 2010
Softcover ISBN: 978-1-4614-2569-4Published: 04 May 2012
eBook ISBN: 978-1-4419-1770-6Published: 10 March 2010
Series ISSN: 2199-2584
Series E-ISSN: 2199-2592
Edition Number: 1
Number of Pages: VIII, 206
Number of Illustrations: 8 b/w illustrations, 11 illustrations in colour
Topics: Cancer Research, Pharmacology/Toxicology