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Nitric Oxide (NO) and Cancer

Prognosis, Prevention, and Therapy

  • Book
  • © 2010

Overview

Editors:
  1. Benjamin Bonavida

    1. Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Los Angeles, USA

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  • the first volume to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. General Overview

    1. Front Matter

      Pages 1-1
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    2. Nitric Oxide and Cancer: An Overview

      • Robert Cheng, Lisa A. Ridnour, Sharon A. Glynn, Christopher H. Switzer, Wilmarie Flores-Santana, Perwez Hussain et al.
      Pages 3-20

  3. Nitric Oxide and the Pathogenesis of Cancer

    1. Front Matter

      Pages 21-21
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    2. A Role for eNOS in Oncogenic Ras-Driven Cancer

      • David F. Kashatus, Christopher M. Counter
      Pages 23-38

    3. Dual Role of Nitric Oxide in Cancer Biology

      • Shehla Pervin, Rajan Singh, Suvajit Sen, Gautam Chaudhuri
      Pages 39-57

    4. Nitric Oxide Expression in Cancer

      • Emanuela Masini, Fabio Cianchi, Rosanna Mastroianni, Salvatore Cuzzocrea
      Pages 59-82

  4. Dual Roles of Nitric Oxide in Protecting or Inducing Cell Death

    1. Front Matter

      Pages 83-83
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    2. S-Nitrosylation – How Cancer Cells Say NO to Cell Death

      • Anand Krishnan V. Iyer, Neelam Azad, Liying Wang, Yon Rojanasakul
      Pages 85-102

    3. Cytotoxic and Protective Activity of Nitric Oxide in Cancers

      • Gen-Ichiro Soma, Chie Kohchi, Hiroyuki Inagawa
      Pages 103-132

    4. Cytotoxic/Protective Activity of Nitric Oxide in Cancer

      • Eun-Kyeong Jo, Hyun-Ock Pae, Yong Chul Lee, Hun-Taeg Chung
      Pages 133-145

    5. Nitric Oxide and Life or Death of Human Leukemia Cells

      • J. Brice Weinberg
      Pages 147-167

    6. Inhibition of Apoptosis by Endogenous Nitric Oxide in Chronic Lymphocytic Leukaemia

      • Christian Billard, Claire Quiney, Jean-Pierre Kolb
      Pages 169-185

  5. Role of Nitric Oxide in Metastasis

    1. Front Matter

      Pages 187-187
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    2. Nitric Oxide: A Rate-Limiting Factor for Metastases Development

      • Angel Ortega, Salvador Mena, José M. Estrela
      Pages 189-207

    3. Nitric Oxide Inhibits Tumor Cell Metastasis via Dysregulation of the NF-κB/Snail/RKIP Loop

      • Stavroula Baritaki, Benjamin Bonavida
      Pages 209-233

  6. Nitric Oxide as a Sensitizing Agent for Chem-Radio-Immunotherapy

    1. Front Matter

      Pages 235-235
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    2. Sensitizing Effect of Nitric Oxide to Cytotoxic Stimuli

      • Peter Siesjö
      Pages 237-252

    3. Nitric Oxide Is a Promising Enhancer for Cancer Therapy

      • Marion Cortier, Lissbeth Leon, Néjia Sassi, Catherine Paul, Jean-François Jeannin, Ali Bettaieb
      Pages 253-263

    4. Role of Nitric Oxide for Modulation of Cancer Therapy Resistance

      • Thomas Efferth
      Pages 265-282
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Keywords

About this book

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

Editors and Affiliations

  • Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Los Angeles, USA

    Benjamin Bonavida

Bibliographic Information

  • Book Title: Nitric Oxide (NO) and Cancer

  • Book Subtitle: Prognosis, Prevention, and Therapy

  • Editors: Benjamin Bonavida

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-4419-1432-3

  • Publisher: Humana New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2010

  • Hardcover ISBN: 978-1-4419-1431-6Published: 17 June 2010

  • Softcover ISBN: 978-1-4614-2611-0Published: 05 September 2012

  • eBook ISBN: 978-1-4419-1432-3Published: 16 June 2010

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: X, 250

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology

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