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  • © 2010

Lung Cancer Metastasis

Novel Biological Mechanisms and Impact on Clinical Practice

  • Will provide important insights into current research in this area

  • The area of lung cancer metastasis is a very timely subject in view that lung cancer remains the number 1 cause of cancer death in both men and women in this country and abroad

  • Includes supplementary material: sn.pub/extras

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xiii
  2. Lung Cancer: Overview

    • Shirish M. Gadgeel, Gregory P. Kalemkerian
    Pages 1-27
  3. Hallmarks of Metastasis

    • M. Roshni Ray, David M. Jablons
    Pages 29-46
  4. Tumor Stem Cells and Metastasis

    • Jaclyn Y. Hung
    Pages 47-63
  5. Epithelial–Mesenchymal Transition as a Mechanism of Metastasis

    • Katia Savary, Stefan Termén, Sylvie Thuault, Venkateshwar Keshamouni, Aristidis Moustakas
    Pages 65-92
  6. Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis

    • Charles Kumar Thodeti, Kaustabh Ghosh
    Pages 93-109
  7. Immunologic Mechanisms in Lung Carcinogenesis and Metastasis

    • Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma, Tonya Walser, Edward Garon et al.
    Pages 111-134
  8. Chemokines in Lung Cancer Metastasis

    • Borna Mehrad, Ellen C. Keeley, Robert M. Strieter
    Pages 155-172
  9. Molecular Control of Lymphatic Metastasis in Lung Cancer

    • Mark M. Fuster, Judith A. Varner
    Pages 173-191
  10. Carcinoma-Associated Fibroblasts in Lung Cancer

    • Roya Navab, Bizhan Bandarchi, Ming-Sound Tsao
    Pages 193-215
  11. The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer

    • Zvi G. Fridlender, M. Cecilia Crisanti, Steven M. Albelda
    Pages 217-239
  12. Experimental Animal Models for Studying Lung Cancer

    • Jiang Liu, Michael R. Johnston
    Pages 241-265
  13. Molecular Imaging in Lung Cancer Metastases

    • Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R. Rao, Brian D. Ross, Alnawaz Rehemtulla
    Pages 267-287
  14. Biomarker Discovery for Metastatic Disease

    • Gilbert S. Omenn, James D. Cavalcoli
    Pages 289-315
  15. Current Clinical Management of Metastatic Lung Cancer

    • Bryan J. Schneider, Suresh S. Ramalingam
    Pages 317-350
  16. Site-Directed Therapy for Lung Cancer Metastases

    • Kevin S Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens, Malini Venkatram, Ella A Kazerooni et al.
    Pages 351-381
  17. Systems Approach for Understanding Metastasis

    • Peter J. Woolf, Angel Alvarez, Venkateshwar G. Keshamouni
    Pages 383-394
  18. Back Matter

    Pages 395-409

About this book

Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large.

In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.

Editors and Affiliations

  • Dept. Internal Medicine, University of Michigan Health System, Ann Arbor, U.S.A.

    Venkateshwar Keshamouni

  • Dept. Internal Medicine, University of Michigan, Ann Arbor, U.S.A.

    Douglas Arenberg, Gregory Kalemkerian

Bibliographic Information

  • Book Title: Lung Cancer Metastasis

  • Book Subtitle: Novel Biological Mechanisms and Impact on Clinical Practice

  • Editors: Venkateshwar Keshamouni, Douglas Arenberg, Gregory Kalemkerian

  • DOI: https://doi.org/10.1007/978-1-4419-0772-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2010

  • Hardcover ISBN: 978-1-4419-0771-4Published: 29 October 2009

  • Softcover ISBN: 978-1-4899-8111-0Published: 26 November 2014

  • eBook ISBN: 978-1-4419-0772-1Published: 18 September 2009

  • Edition Number: 1

  • Number of Pages: XIII, 409

  • Topics: Cancer Research, Oncology

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access