The Local Cardiac Renin-Angiotensin Aldosterone System

1. Front Matter

   Pages i-xii

   PDF

2. Are Local Renin–Angiotensin Systems the Focal Points for Understanding Salt Sensitivity in Hypertension?

   • Edward D. Frohlich

   Pages 1-6

3. Newer Insights into the Biochemical Physiology of the Renin–Angiotensin System: Role of Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and Angiotensin-(1-12)

   • Carlos M. Ferrario, Jewell A. Jessup, Jasmina Varagic

   Pages 7-17

4. Renin, Prorenin, and the (Pro)renin Receptor

   • Genevieve Nguyen, Aurelie Contrepas

   Pages 19-28

5. Intracellular Accumulation and Nuclear Trafficking of Angiotensin II and the Angiotensin II Type 1 Receptor

   • Julia L. Cook, Richard N. Re

   Pages 29-41

6. Pathophysiologic Implications of Cell Swelling in the Failing Heart: Influence of Intracrine and Extracellular Renin–Angiotensin Systems

   • Walmor C. De Mello

   Pages 43-49

7. Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage

   • Xiaoujun Liu, Christopher O.C. Bellamy, Linda J. Mullins, Donald Dunbar, John J. Mullins

   Pages 51-66

8. Alternative Renin Transcripts and Functions of Cytoplasmatic Renin

   • Jörg Peters, Heike Wanka

   Pages 67-73

9. Novel Aspects of the Cardiac Renin–Angiotensin System

   • Vivek P. Singh, Kenneth M. Baker, Rajesh Kumar

   Pages 75-89

10. Intracrine Function from Angiotensin to Stem Cells

    • Richard N. Re, Julia L. Cook

    Pages 91-100

11. Renin Cell Identity and Homeostasis

    • R. Ariel Gómez, Maria Luisa S. Sequeira Lopez, Xuan Jin, Magali Cordaillat, Ellen Steward Pentz

    Pages 101-106

12. Role of Renal Aminopeptidases and Angiotensin Type-2 (AT2) Receptors in Sodium Excretion and Hypertension

    • Robert M. Carey, Shetal H. Padia, John J. Gildea, Susanna R. Keller

    Pages 107-120

13. Intrarenal Angiotensin II Augmentation in Hypertension

    • Romer A. Gonzalez-Villalobos, L.G. Navar

    Pages 121-131

14. Collecting Duct Renin: A Critical Linkin Angiotensin II-Dependent Hypertension

    • Minolfa C. Prieto, L. Gabriel Navar

    Pages 133-141

15. Renin–Angiotensin–Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease

    • Arantxa González, Susana Ravassa, Begoña López, Javier Beaumonta, Javier Díez

    Pages 143-150

16. Upregulation of Angiotensin II Type 2 Receptor (agtr2) Attenuates Atherosclerotic Lesion Formation and Enhances Apoptosis in the LDL Receptor Knockout Mice Fed High Cholesterol Diet

    • Jawahar L. Mehta, Magomed Khaidakov, Changping Hu, Giusto Spagnolli, Dayuan Li

    Pages 151-163

17. Salt and Heart: RAAS Involvement

    • Jasmina Varagic, Carlos M. Ferrario

    Pages 165-173

18. Cardiac Effects of Aldosterone, the Bad, but Is There Also a Good?

    • Ludovic Bénard, Bernard Swynghedauw, Paul Milliez, Marie-Lory Ambroisine, Smail Messaoudi, Jane-Lise Samuel et al.

    Pages 175-180

19. Back Matter

    Pages 181-184

    PDF

With great pleasure we present our Third International Workshop on The Local C- diac Renin–Angiotensin–Aldosterone System (RAAS), held at the Ochsner Clinic Foundation in November 2008. When this meeting was rst organized in 2002, we were pleased that all who were invited to participate in our rst workshop attended our program; and what is most satisfying, all of these participants returned for the second and this, the third workshop. In addition, we are delighted that a number of additional workers in this growing eld of investigation joined us for this third program. Over the years since our rst workshop, there is little doubt as to the existence of a local RAAS in the heart. Indeed, there is substantial evidence as to the existence of other local systems in brain, vessels, adrenal, and, as presented in the current workshop, the kidneys. What is even more stimulating intellectually, through dup- cation of local RAAS systems a remarkable yin-yang biological balance is provided by nature. Thus, in the current third workshop considerable evidence has accu- lated over the years for complicated local systems that serve to provide exquisite and unique local control of local organ functions.

• Angiotensin II
• aldosterone
• cardiovascular
• circulation
• genetics
• heart
• hormone
• hypertension
• steroid

From the reviews of the second edition: “This book disseminates new findings about the local renin-angiotensin aldosterone system (RAAS) in the cardiovascular system and the kidneys … . This is a great resource for anyone doing research into any cell or tissue that is regulated or potentially regulated by RAAS. … Students beginning careers in research in this field will find this to be a great account of current research … . As a gastrointestinal physiologist with a long-time interest in hormonal regulation of cell function, I found this book intriguing.” (David L. Osborne, Doody’s Review Service, June, 2010)

• Ochsner Clinic Foundation, New Orleans, U.S.A.

  Edward D. Frohlich, Richard N. Re

Policies and ethics