Overview
Presents readers with a coherent overview of cutting edge information on glutamate metabolism in brain
Examines the role of glutamate transporters and the involvement of glutamate receptors in the pathogenesis of acute neural trauma and neurodegenerative diseases
Includes information on the treatment of these diseases with endogenous and exogenous antioxidants and glutamate receptor antagonists
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Table of contents (11 chapters)
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Front Matter
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Back Matter
Keywords
About this book
In the past decade, our understanding of the biochemistry, molecular biology, and neuropathology of the glutamate transporters and receptors has exploded. It is becoming increasingly evident that molecular mechanisms, which govern the transfer of the death signal from the neural cell surface to the nucleus, depend on lipid mediators and on cross talk among excitotoxicity, oxidative stress, and neuroinflammation, and that interactions among these three processes play a major role in neuronal cell death during acute neural trauma and neurodegenerative disease. These processes may be primary initiating points in neurodegeneration or they may be the end result of the neurodegenerative process itself.
Neurochemical Aspects of Excitotoxicity provides extensive insight into glutamate transporters and receptors, including their role in the brain with other neurochemical parameters in excitotoxicity, and possible treatments. This book will be of interest scientists already working in the field of excitotoxicity who are interested in gaining a broader understanding of this complicated subject area, as well as graduate students and neurologists who are curious about a common cause of neuronal injury and neurological disorders.
Authors and Affiliations
Bibliographic Information
Book Title: Neurochemical Aspects of Excitotoxicity
Authors: Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks
DOI: https://doi.org/10.1007/978-0-387-73023-3
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag New York 2008
Hardcover ISBN: 978-0-387-73022-6Published: 17 October 2007
Softcover ISBN: 978-1-4419-2504-6Published: 29 October 2010
eBook ISBN: 978-0-387-73023-3Published: 20 November 2007
Edition Number: 1
Number of Pages: XVIII, 290
Topics: Neurosciences, Neurology, Biochemistry, general, Medical Biochemistry