Cytokines and Cancer

1. Front Matter

   Pages i-xiii

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2. Basic Science Research

   1. Polypeptide Growth Factors and Their Receptors

      • Anupama Gururaj, Rakesh Kumar

      Pages 1-14

   2. Chemokines and Cancer

      • Thomas T. Murooka, Sarah E. Ward, Eleanor N. Fish

      Pages 15-44

   3. Interferons

      • Simrit Parmar, Leonidas C. Platanias

      Pages 45-68

   4. Cytokines and Lymphomas

      • Georgios V. Georgakis, Anas Younes

      Pages 69-102

   5. Pro-apototic and Anti-apoptotic Effects of Tumor Necrosis Factor in Tumor Cells

      • Bharat B. Aggarwal, Yasunari Takada

      Pages 103-127

   6. Transforming Growth Factor Beta and Breast Cancer

      • Virginia Kaklamani, Boris Pasche

      Pages 129-156

   7. Transforming Growth Factor Beta and Prostate Cancer

      • Brian Zhu, Natasha Kyprianou

      Pages 157-173

   8. Angiostatin

      • Jennifer A. Doll, Gerald A. Soff

      Pages 175-204

3. Clinical and Translational Research

   1. Interferons in the Treatment of Solid Tumors

      • Stergios Moschos, Sai Varanasi, John M. Kirkwood

      Pages 207-241

   2. Targeting Cytokine Receptors and Pathways in the Treatment of Breast Cancer

      • Ingrid A. Mayer

      Pages 243-262

   3. Interleukin-2 in the Treatment of Renal Cell Carcinoma and Malignant Melanoma

      • John W. Eklund, Timothy M. Kuzel

      Pages 263-287

   4. Cytokine Targeted Treatments for Lung Cancer

      • Jyoti Patel

      Pages 289-311

   5. Cytokines in the Treatment of Acute Leukemias

      • Farhad Ravandi, Partow Kebriaei

      Pages 313-331

   6. Cytokines in Hematopoietic Stem Cell Transplantation

      • Jayesh Mehta

      Pages 333-351

   7. Novel Cytokines in the Treatment of Malignancies

      • Robin Parihar, William E. Carson III

      Pages 353-373

4. Back Matter

   Pages 375-377

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Dramatic advances have occurred over the last few years in the research field of cancer biology. There has been a constant accumulation of important new information, resulting in a gradual transformation on the perceptions that exist among scientists regarding mechanisms by which the malignant phenotype develops. The recent developments in cancer research have also had a substantial impact in efforts towards the development of new cancer therapies. One of the most explosive and rapidly advancing research areas has been the area of cytokines and cancer. Many perceptions have changed from the original discovery, decades ago, of the interferon, to the current state of the art cytokine research. It is now well recognized that many cytokines play important roles in normal cellular functions, while some of them have prominent roles in the pathophysiology of cancer. It is also now firmly established that several cytokines promote the growth of cancer cells, while others act as suppressors of malignant cell proliferation. The importance of the cytokine signaling field in cancer is reflected by the development of multiple treatments that have been introduced in clinical oncology over the last few years. Understanding the physiological functions of cytokines, as well as their precise roles in the pathogenesis of certain malignancies, is extremely important in the current clinical era.

• carcinoma
• cell
• cytokine
• cytokines
• hematopoietic stem cell
• hematopoietic stem cell transplantation
• interferon
• leukemia
• lymphoma
• melanoma
• prostate cancer
• stem cell
• stem cell transplantation
• transplantation
• tumor

• Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, USA

  Leonidas C. Platanias

Policies and ethics