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Toll and Toll-Like Receptors:

An Immunologic Perspective

  • Book
  • © 2005

Overview

Authors:
  1. Tina Rich

    1. Department of Pathology, University of Cambridge, Cambridge, UK

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  • Toll and Toll Like Recptors is an eclectic collection of essays, spanning academia and industry.
  • This volume illustrates how Toll and the Toll-like receptors work and the consequences for us all when they fail.
  • It looks at Toll structures, what they recognize, and what they ‘might’ recognize.
  • This exiting book will be of interest to academics and practitioners in industry, as well as to post graduate students in immunology.

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction

    • Elizabeth H. Bassett, Tina Rich
    Pages 1-17

  3. The Function of Toll-Like Receptors

    • Zlatko Dembic
    Pages 18-55

  4. Structures and Motifs Involved in Toll Signaling

    • Monique Gangloff, Phumzile L. Ludidi, Nicholas J. Gay
    Pages 56-93

  5. “Supramolecular” Activation Clusters in Innate Immunity

    • Martha Triantafilou, Kathy Triantafilou
    Pages 94-109

  6. Interleukin-1 Receptor/Toll-Like Receptor Signaling

    • Harald Wajant, Peter Scheurich, Frank Henkler
    Pages 110-130

  7. Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response

    • Claudia Wietek, Luke A. J. O’Neill
    Pages 131-146

  8. The Induction of Dendritic Cell Activation and Maturation by Toll-Like Receptor Signaling

    • Tsuneyasu Kaisho, Shizuo Akira
    Pages 147-161

  9. Pathogen Avoidance Using Toll Signaling in C. elegans

    • Nathalie Pujol, Jonathan J. Ewbank
    Pages 162-167

  10. Forward Genetic Analysis of TLR Pathways

    • Bruce Beutler, Kasper Hoebe, Philippe Georgel, Xin Du
    Pages 168-180

  11. Agonists of Toll-Like Receptor 9

    • Ekambar R. Kandimalla, Sudhir Agrawal
    Pages 181-212

  12. Back Matter

    Pages 213-218
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Keywords

About this book

Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. ^ Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ­ ing it as a ^^MddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to reveal. Toll-Like Receptor (TLR) biology would prove to be one of these secrets. Analyses of the evolution of these receptors (Tolls and TLRs) have also helped us to rethink immune system phylogeny. In the first part of this chapter the history of the discovery of Toll and TLR biology is described. The evolution of the TLR genes and theories of immune function are covered in later sections. The remainder of this book presents work from nine groups active in the field. In the first chapter, "The Function of Toll-Like Receptors", Zlatko Dembic sets the stage by introducing us to many of the components of the immune system and their relationships vis a vis Toll receptors. Zlatko finishes his chapter with a discussion about current immune system models and contributes his own 'integrity model'. Work from the laboratory of Nicholas Gay follows this in "Structures and Motifs Involved in Toll Signaling".

Authors and Affiliations

  • Department of Pathology, University of Cambridge, Cambridge, UK

    Tina Rich

Bibliographic Information

  • Book Title: Toll and Toll-Like Receptors:

  • Book Subtitle: An Immunologic Perspective

  • Authors: Tina Rich

  • Series Title: Molecular Biology Intelligence Unit

  • DOI: https://doi.org/10.1007/b139083

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-306-48237-3Published: 07 January 2005

  • Softcover ISBN: 978-1-4419-3438-3Published: 19 November 2010

  • eBook ISBN: 978-0-387-27445-4Published: 11 March 2007

  • Series ISSN: 1431-0414

  • Edition Number: 1

  • Number of Pages: X, 218

  • Number of Illustrations: 70 b/w illustrations, 6 illustrations in colour

  • Topics: Cell Biology, Immunology

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