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Effect of oral administration of nutmeg extract on american house dust mite (Dermatophagoides farinae) extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

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Abstract

The effects of oral administration of nutmeg extract (NE) on atopic dermatitis (AD) were evaluated using NC/Nga mice treated with American house dust mite (Dermatophagoides farinae) extract. In this mouse model of AD, NE suppressed transepidermal water loss, erythema, and the production of serum immunoglobulin E, interleukin (IL)-4, and interferon-γ by auxillary lymph node cells. In addition, NE reduced epidermal thickening and inflammatory cell infiltration into the skin. In skin lesions, NE suppressed IL-13 and tumor necrosis factor (TNF)-α mRNA expression. In the spleen, NE upregulated T-box transcription factor expressed in T cells and downregulated GATA-binding protein 3, which are involved in T helper cell differentiation. Our findings suggest that NE ameliorates AD and may be a potential nutraceutical candidate for treating AD.

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Authors and Affiliations

  1. Department of Biomaterials Science and Engineering, Yonsei University, Seoul, 120-749, Korea

    Hee-Chul Chung & Jae-Kwan Hwang

  2. Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea

    Myung-Suk Kim, Suk-Yeong Mun, Bo-Kyung Sa & Jae-Kwan Hwang

  3. Newtree Co., Ltd., Seongnam, Gyeonggi, 462-120, Korea

    Hee-Chul Chung, Jae-Yoon Chung & Do-Un Kim

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  1. Hee-Chul Chung
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  2. Myung-Suk Kim
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  3. Suk-Yeong Mun
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  4. Bo-Kyung Sa
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  5. Jae-Yoon Chung
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  7. Jae-Kwan Hwang
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Correspondence to Jae-Kwan Hwang.

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Chung, HC., Kim, MS., Mun, SY. et al. Effect of oral administration of nutmeg extract on american house dust mite (Dermatophagoides farinae) extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Food Sci Biotechnol 21, 559–564 (2012). https://doi.org/10.1007/s10068-012-0071-8

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  • DOI: https://doi.org/10.1007/s10068-012-0071-8

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