Abstract
A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.
Sommario
Un uomo di 65 anni affetto da mieloma multiplo IgG lambda ha sviluppato una forma severa di polineuropatia con prevalente coinvolgimento della sensibilità termo-dolorifica e del sistema autonomico. Sebbene la presentazione clinica suggerisse una neuropatia da amiloidosi, la biopsia del nervo ha messo in evidenza le caratteristiche immunoistochimiche ed ultrastrutturali della malattia da depositi di catene leggere (LCDD). Vengono riportate, per la prima volta, le caratteristiche morfologiche e cliniche della neuropatia da depositi di catene leggere.
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Grassi, M.P., Clerici, F., Perin, C. et al. Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient. Ital J Neuro Sci 19, 229–233 (1998). https://doi.org/10.1007/BF02427609
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DOI: https://doi.org/10.1007/BF02427609