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“MCC SANAQ®burst”—A New Type of Cellulose and its Suitability to Prepare Fast Disintegrating Pellets

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Abstract

Introduction

Microcrystalline cellulose (MCC) is the commonly used pelletization aid in wet extrusion-spheronization processes. MCC has the structure of cellulose I and is denoted as MCC I. Recently, MCC II, a different polymorphic type of MCC, became commercially available, known under the name MCC SANAQ®burst. Due to the fact, that MCC II can be used as a filler and a disintegrant in tableting, MCC SANAQ®burst was investigated as new pelletization aid with the goal to prepare disintegrating pellets.

Materials

MCC II pellets were compared to the corresponding conventional pellets, manufactured on the basis of MCC I, namely Avicel® PH 102. Formulations with 10%, 20%, and 50% of either MCC I or MCC II as pelletization aids were produced.

Methods

One series of binary mixtures, contained lactose monohydrate as filler and a second series chloramphenicol as model drug. All pellets were characterized by their yield, aspect ratio, equivalent diameter, water content, tensile strength, disintegration behavior and—if applicable—drug release.

Results and Discussion

The production of pellets with sufficient quality properties by addition of 10%, 20%, and 50% of MCC II as pelletization aid was possible. In contrast to MCC I pellets, MCC II-based pellets showed disintegration resulting in a much faster drug release.

Conclusion

MCC SANAQ®burst is a promising pelletization aid providing disintegrating and fast-dissolving pellets.

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Acknowledgment

The authors acknowledge the financial support and the gift of MCC SANAQ®burst from Pharmatrans SANAQ Ltd, Basel, Switzerland. Furthermore, the authors are grateful to SciConcept for their support regarding crystal structure analyses.

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Authors and Affiliations

  1. Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Universitaetsstr. 1, 40225, Duesseldorf, Germany

    Cornelia Krueger, Markus Thommes & Peter Kleinebudde

Authors
  1. Cornelia Krueger
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  2. Markus Thommes
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  3. Peter Kleinebudde
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Correspondence to Peter Kleinebudde.

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Krueger, C., Thommes, M. & Kleinebudde, P. “MCC SANAQ®burst”—A New Type of Cellulose and its Suitability to Prepare Fast Disintegrating Pellets. J Pharm Innov 5, 45–57 (2010). https://doi.org/10.1007/s12247-010-9080-4

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