Bennett and colleagues present an innovative patient-centered research methodology engaging multiple stakeholders, including groups of patients and caregivers, to adapt clinical practice guidelines (CPG) to patients with multiple chronic conditions (MCC). The authors used a modified Delphi method to identify key topics in order to translate them into relevant questions for people with MCC.1

Despite several limitations of this qualitative study, including the use of a sample of potentially motivated selected patients, or predefining the list of high-priority topics from a program without patient-stakeholder input, and allowing only two final topics to be identified by participants (‘optimal blood pressure goals’ and ‘diabetes medication management’), we can learn from this experience by understanding contextual factors of health and care priorities for people with MCC.2

The most relevant outcomes identified from the study could be classified based on several categories: self-perception of health status (as physical function and energy or emotional health and well-being), treatment effects (as avoidance of treatment burden, side effects and risks), health care system navigation (including communication and coordination) and prevention of adverse long-term health outcomes. Some of these structural aspects of care were considered key elements of high-quality primary care for vulnerable elders in previous research.3

This approach supports the notion that focusing on patients’ priorities and making decisions based on patients’ views, not on diseases, is possible4 not only in clinical settings, but also in the translation of evidence-based medicine to the care of people with MCC.5

With this study, the authors have opened the door to new evidence perspectives in the field of MCC care by including patients’ perceptions in the methodology of developing CPGs. This approach should be replicated in future CPG development, with implications for evidence reviewers, CPG developers, researchers, clinicians and policymakers worldwide.