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Nichtinvasive Diagnostik von Hautfunktionen

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Zusammenfassung

Nichtinvasive Untersuchungstechniken von Hautfunktionen werden in der Dermatologie und Kosmetologie zunehmend eingesetzt. Durch den Einsatz dieser Techniken lassen sich an der lebendigen Haut Hautfunktionen erfassen, die der bloßen klinischen Untersuchung und sensorischen Wahrnehmung oft nicht oder nur unzureichend zugänglich sind. Morphologische und funktionelle Parameter der Haut können durch moderne Techniken objektiv und reproduzierbar dargestellt werden; eine Tatsache, der besonders im Zeitalter der evidencebasierten Medizin eine große Bedeutung zukommt. Die erhobenen Daten lassen sich quantifizieren und mittels elektronischer Datenverarbeitung verwalten. In einer exemplarischen Übersicht werden gängige Verfahren der Hautfunktionsmessungen beschrieben und ihre Einsatzmöglichkeiten aufgezeigt.

Abstract

Noninvasive investigation of skin functions is increasingly employed in dermatology and cosmetology. It enables one to study aspects of skin functions that cannot always be appreciated by sensory perception. Noninvasive methods permit objective and reproducible investigation of distinct biophysical parameters. In the age of evidence-based medicine this becomes more and more important. Biophysical data can be quantified, analyzed, and stored electronically. In an overview, selected noninvasive techniques of skin function testing are introduced and their relevance in dermatology, dermatopharmacology, and cosmetology is discussed.

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Literatur

  1. Altmeyer P, Hoffmann K, Stücker M (1997) Kutane Mikrozirkulation. Springer, Berlin Heidelberg New York Tokyo

  2. Auer T, Bacharach-Buhles M, el Gammal S et al. (1994) The hyperperfusion of the psoriatic plaque correlates histologically with dilatation of vessels. Acta Derm Venerol 186:30–32

    CAS  Google Scholar 

  3. Berardesca E, Elsner P, Wilhelm KP, Maibach (1995) Bioengineering of the skin: methods and instrumentation. CRC Press, Boca Raton

    Google Scholar 

  4. Berardesca E, Leveque JL, Masson P, European Group for Efficacy Measurements on Cosmetics and Other Topical Products (EEMCO Group) (2002) EEMCO guidance for the measurement of skin microcirculation. Skin Pharmacol Appl Skin Physiol 15:442–456

    Article  PubMed  Google Scholar 

  5. Bernardi L, Rossi M, Fratino P et al. (1989) Relationship between changes in human skin blood flow and autonomic tone. Microvasc Res 37:16–27

    PubMed  Google Scholar 

  6. Bircher A, Roskos K, Maibach H, Guy R (1993) Laser Doppler measured cutaneous blood flow: effects with age. In: Leveque JL, Agache P (eds) Aging skin: properties and functional changes. Dekker, New York

  7. Birklein F, Riedl B, Griessinger N, Neundörfer B (1999) Komplexes regionales Schmerzsyndrom. Nervenarzt 70:335–341

    Article  CAS  PubMed  Google Scholar 

  8. Braune C, Erbguth F, Birklein F (2001) Dose thresholds and duration of the local anhidrotic effect of botulinum toxin injections: measured by sudometry. Br J Dermatol 144:111–117

    Article  CAS  PubMed  Google Scholar 

  9. Braun-Falco O, Korting HC (1986) Der normale pH-Wert der menschlichen Haut. Hautarzt 37:126–129

    CAS  PubMed  Google Scholar 

  10. Burckhardt W (1961) In: Gottron HA, Schönfeld W (Hrsg) Dermatologie und Venerologie, Band I. Thieme, Stuttgart, S 194–195

  11. Courage W (1994) Hardware and measuring principle: Corneometer. In: Elsner P, Berardesca E, Maibach HI (eds): Bioengineering and the skin: water and stratum corneum. CRC Press, Boca Raton, pp 171–175

  12. Fischer TW, Wigger-Alberti W, Elsner P (2001) Assessment of „dry skin“: current bioengineering methods and test designs. Skin Pharmacol Appl Skin Physiol 14:183–195

    Article  CAS  PubMed  Google Scholar 

  13. Fullerton A, Fischer T, Lathi A et al. (1996) Guidelines for the measurement of skin colour and erythema. A report from the standardization group of the European Society of Contact Dermatitis. Contact Dermat 35:1–10

    CAS  Google Scholar 

  14. Fullerton A, Stücker M, Wilhelm KP et al. (2002) Guidelines for visualization of cutaneous blood flow by laser Doppler perfusion imaging. A report from the Standardization Group of the European Society of Contact Dermatitis based upon the HIRELADO European community project. Contact Dermat 46:129–140

    Article  CAS  Google Scholar 

  15. Gambichler T, Avermaete A, Bader A et al. (2001) Ultraviolet protection by summer textiles. Ultraviolet transmission measurements verified by determination of the minimal erythema dose with solar-simulated radiation. Br J Dermatol 144:484–489

    Article  CAS  PubMed  Google Scholar 

  16. Gambichler T, Bechara FG, Stücker M et al. (2003) Bioengineering of the skin: non-invasive methods for the evaluation of efficacy. In: Wohlrab J, Neubert R, Marsch W (eds) Trends in dermatopharmacy. Trends Clin Exp Dermatol, Vol. 1. Shaker, Aachen

  17. Gloor M, Strack R, Oschmann H, Friederich HC (1972) Über den Einfluß der Oberflächenlipide auf das Ergebnis der Alkaliresistenzbestimmung nach Burckhardt. Berufsdermatosen 20:105–110

    CAS  PubMed  Google Scholar 

  18. Habig J, Vocks E, Kautzky F et al. (1996) Einfluss einmaliger UVA- und UVB-Bestrahlung auf Oberflächenbeschaffenheit und viskoelastische Eigenschaften der Haut in vivo. Hautarzt 47:515–520

    Article  CAS  PubMed  Google Scholar 

  19. Hoffmann K, Auer T, Stücker M et al. (1994) Evaluation of the efficacy of H1-blockers by non-invasive measurement techniques. Dermatology 189:146–151

    CAS  PubMed  Google Scholar 

  20. Hoffmann K, Auer T, Stücker M et al. (1998) Comparison of skin atrophy and vasoconstriction due to mometasone furoate, methylprednisolone and hydrocortisone. J Eur Acad Dermatol Venerol 10:137–142

    Article  CAS  Google Scholar 

  21. Kelly RI (1995) The effects of aging on the cutaneous microvasculature. J Am Acad Dermatol 33:749–756

    CAS  PubMed  Google Scholar 

  22. Knüttel A, Boehlau-Godau M (2000) Spatially confined and temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography. J Biomedical Optics 5:83–91

    Article  Google Scholar 

  23. Kreuter A, Gambichler T, Sauermann K et al. (2002) Extragenital lichen sclerosus successfully treated with topical calcipotriol: evaluation by in vivo confocal laser scanning microscopy. Br J Dermatol 146:332–333

    Article  CAS  PubMed  Google Scholar 

  24. Lang E, Foerster A, Pfannmüller D, Handwerker HO (1993) Quantitative assessment of sudomotor activity by capacitance hygrometrie. Clin Aut Res 3:107–115

    CAS  Google Scholar 

  25. Löffler H, Effendy I, Happle R (1999) Epikutane Testung mit Natriumlaurylsulfat: Nutzen und Grenzen in Forschung und Praxis. Hautarzt 50:769–778

    Article  PubMed  Google Scholar 

  26. Nuutinen J, Alanen E, Autio P et al. (2003) A closed unventilated chamber for the measurement of transepidermal water loss. Skin Res Technol 9:85–89

    PubMed  Google Scholar 

  27. Obeid AN, Barnett NJ, Dougherty G, Ward G (1990) A critical review of laser doppler flowmetry. J Med Eng Technol 14:178–181

    CAS  Google Scholar 

  28. Pierard GE (1998) EEMCO guidance to the assessment of skin colour. J Eur Acad Dermatol Venerol 10:1–11

    Article  CAS  Google Scholar 

  29. Pinnagoda J, Tupker RA, Agner T, Serup J (1990) Guidelines for transepidermal water loss measurement. Contact Dermatitis 22:164–178

    CAS  PubMed  Google Scholar 

  30. Serup J, Agner T (1990) Colorimetric quantification of erythema—a comparison between two colorimeters (Lange Micro Color and Minolta Chroma Meter CR-200) with a clinical scoring scheme and laser-doppler flowmetry. Clin Exp Dermatol 15:267–272

    CAS  PubMed  Google Scholar 

  31. Spoo J, Wigger-Alberti W, Berndt U et al. (2002) Skin cleansers: three test protocols for the assessment of irritancy ranking. Acta Derm Venerol 82:13–17

    Article  CAS  PubMed  Google Scholar 

  32. Stücker M (1996) Durchblutungsstörungen bei Kollagenosen. In: Altmeyer P, Dirschka T, Hartwig R (Hrsg) Kollagenosesprechstunde. Reha Verlag, Bonn, S 163–172

  33. Stücker M, Heese A, el Gammal C et al. (1998) Quantification of vascular dysregulation in atopic dermatitis using laser Doppler perfusion imaging. Skin Res Technol 4:9–13

    Google Scholar 

  34. Stücker M, Heese A, Röchling A et al. (1995) Precision of laser-Doppler-scanning in clinical use. J Clin Exp Dermatol 20:371–376

    Google Scholar 

  35. Stücker M, Hoffmann M, Memmel U et al. (2002) In-vivo-Differenzierung von pigmentierten Hauttumoren mittels Laser-Doppler-Perfusion-Imaging. Hautarzt 53:244–249

    Google Scholar 

  36. Stücker M, Jeske M, Hoffmann K, Altmeyer P (1995) Laser Doppler Scanning bei progressiver systemischer Sklerodermie. Phlebologie 24:9–14

    Google Scholar 

  37. Stücker M, Memmel U, Altmeyer P (2000) Transkutane Sauerstoffpartialdruck- und Kohlendioxidpartialdruckmessung—Verfahrenstechnik und Anwendungsgebiete. Phlebologie 29:81–91

    Google Scholar 

  38. Stücker M, Reuther T, Hoffmann K et al. (1995) Nicht invasive Evaluierung der kutanen Mikrozirkulation. Akt Dermatol 21:4–10

    Google Scholar 

  39. Stücker M, Struk A, Altmeyer P et al. (2002) The cutaneous uptake of atmospheric oxygen contributes significantly to the oxygen supply of human dermis und epidermis. J Physiol 538:985–994

    Article  Google Scholar 

  40. Suttgen O, Ott A, Flesch U (1989) Measurement of skin temperature. In: Leveque JL (ed) Cutaneous investigation in health and disease. Dekker, New York, pp 275–322

  41. Thum J, Caspary L, Creutzig A et al. (1997). Nicht-invasive Bestimmung von Sauerstoffsättigung und Konzentration des dermalen Hämoglobins bei Patienten mit peripherer arterieller Verschlusskrankheit. Vasa 26:11–17

    CAS  PubMed  Google Scholar 

  42. Wahlberg JE, Nilsson G (1984) Skin irritancy from propylen glycol. Acta Derm Venerol 64:286–290

    CAS  PubMed  Google Scholar 

  43. Welzel J (2001) Optical coherence tomography in dermatology: a review. Skin Res Technol 7:1–9

    Article  CAS  PubMed  Google Scholar 

  44. Wilkin JK, Trotter K (1987) Cognitive reactivity and cutaneous blood flow. Arch Derm 123:1503

    Article  CAS  PubMed  Google Scholar 

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Hanau, A., Stücker, M., Gambichler, T. et al. Nichtinvasive Diagnostik von Hautfunktionen. Hautarzt 54, 1211–1223 (2003). https://doi.org/10.1007/s00105-003-0649-4

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