1. A novel synthetic DNA minor groove binder, MS-247: antitumor activity and cytotoxic mechanism

   • Y. Matsuba
   • H. Edatsugi
   • O. Nakanishi

   ORIGINAL ARTICLE Pages: 1 - 9

2. Pegylated liposome-encapsulated doxorubicin and cisplatin in the treatment of head and neck xenograft tumours

   • Kevin J. Harrington
   • Gail Rowlinson-Busza
   • J. Simon Stewart

   ORIGINAL ARTICLE Pages: 10 - 18

3. Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis

   • Merry L. Tetef
   • Kim A. Margolin
   • Edward M. Newman

   ORIGINAL ARTICLE Pages: 19 - 26

4. Evaluation of toremifene for reversal of multidrug resistance in renal cell cancer patients treated with vinblastine

   • Jeremy P. Braybrooke
   • Katherine A. Vallis
   • Denis C. Talbot

   ORIGINAL ARTICLE Pages: 27 - 34

5. Effects of the aromatase inhibitor anastrozole on serum oestrogens in Japanese and Caucasian women

   • Mitchell Dowsett
   • Kirsteen Donaldson
   • Roger Yates

   ORIGINAL ARTICLE Pages: 35 - 39

6. Pharmacokinetics of 2-chloro-2′-deoxyadenosine administered subcutaneously or by continuous intravenous infusion

   • Theodor Sonderegger
   • Daniel C. Betticher
   • Bernhard H. Lauterburg

   ORIGINAL ARTICLE Pages: 40 - 42

7. Dose escalation and pharmacokinetic study of irinotecan in combination with paclitaxel in patients with advanced cancer

   • John R. Murren
   • Kathleen Peccerillo
   • Yung chi Cheng

   ORIGINAL ARTICLE Pages: 43 - 50

8. Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats

   • Kunihiro Yoshisue
   • Kazue Hironaga
   • Yasuro Kawaguchi

   ORIGINAL ARTICLE Pages: 51 - 56

9. Feasibility and pharmacokinetics of intraperitoneal suramin in advanced malignancy

   • Anneke M. Westermann
   • Ria Dubbelman
   • Sjoerd Rodenhuis

   ORIGINAL ARTICLE Pages: 57 - 62

10. Primary treatment of low-grade non-Hodgkin's lymphoma using an all oral anthracycline-containing regimen, chlorambucil, idarubicin, dexamethasone (CID) – a phase II study

    • Penelope Taylor
    • Graham Jackson
    • Stephen Proctor

    ORIGINAL ARTICLE Pages: 63 - 68

11. Maximum tolerated doses of methotrexate and 7-hydroxy-methotrexate in a model of acute toxicity in rats

    • Ole-Martin Fuskevåg
    • Christel Kristiansen
    • Jarle Aarbakke

    ORIGINAL ARTICLE Pages: 69 - 73

12. Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenografts in vivo

    • Paula B. Caffrey
    • Gerlad D. Frenkel

    ORIGINAL ARTICLE Pages: 74 - 78

13. A peptidomimetic inhibitor of ras functionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility

    • F. M. Sirotnak
    • Laura Sepp-Lorenzino
    • Howard I. Scher

    ORIGINAL ARTICLE Pages: 79 - 83

14. Erratum: Cancer Chemother Pharmacol 45:345–349

    Pages: 84 - 84