Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
Authors (first, second and last of 30)
Volume 7, issue 1, December 2012
61 articles in this issue
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Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
Authors (first, second and last of 5)
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Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Authors (first, second and last of 11)
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The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
Authors (first, second and last of 8)
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Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegansfor drug screening for Alzheimer’s disease
Authors (first, second and last of 11)
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Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
Authors (first, second and last of 8)
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Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
Authors (first, second and last of 11)
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Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
Authors (first, second and last of 12)
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Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease
Authors (first, second and last of 9)
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Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
Authors (first, second and last of 8)
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IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery
Authors (first, second and last of 8)
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Identification of BACE2 as an avid ß-amyloid-degrading protease
Authors (first, second and last of 5)
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Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Authors (first, second and last of 5)
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ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
Authors (first, second and last of 7)
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Exosomal cell-to-cell transmission of alpha synuclein oligomers
Authors (first, second and last of 8)
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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
Authors (first, second and last of 5)
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Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
Authors (first, second and last of 10)
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Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
Authors (first, second and last of 11)
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Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Authors (first, second and last of 12)
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Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
Authors (first, second and last of 6)
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Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level
Authors (first, second and last of 6)
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Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system
Authors (first, second and last of 5)
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Progranulin regulates neuronal outgrowth independent of Sortilin
Authors (first, second and last of 11)
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Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach
Authors (first, second and last of 4)
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LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
Authors (first, second and last of 6)
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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Authors (first, second and last of 7)
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Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
Authors (first, second and last of 4)
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A molecular signature in blood identifies early Parkinson’s disease
Authors (first, second and last of 13)
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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Authors (first, second and last of 17)
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Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
Authors (first, second and last of 10)
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Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
Authors (first, second and last of 6)
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Regulation of mitochondrial permeability transition pore by PINK1
Authors (first, second and last of 8)
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Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia
Authors (first, second and last of 14)
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Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPreslevel disparity
Authors (first, second and last of 6)
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Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia
Authors (first, second and last of 5)
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Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects
Authors (first, second and last of 13)
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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
Authors (first, second and last of 7)
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Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling
Authors (first, second and last of 9)
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Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
Authors (first, second and last of 34)
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Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
Authors (first, second and last of 11)
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Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Authors (first, second and last of 11)
